FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056136674> ?p ?o ?g. }

• W2056136674 endingPage "e88730" @default.
• W2056136674 startingPage "e88730" @default.
• W2056136674 abstract "Background Endothelin-1 participates in the pathophysiology of heart failure. The reasons for the lack of beneficial effect of endothelin antagonists in heart failure patients remain however speculative. The anti-apoptotic properties of ET-1 on cardiomyocytes could be a reasonable explanation. We therefore hypothesized that blocking the pro-apoptotic TNF-α pathway using pentoxifylline could prevent the deleterious effect of the lack of ET-1 in a model for heart failure. Methods We performed transaortic constriction (TAC) in vascular endothelial cells specific ET-1 deficient (VEETKO) and wild type (WT) mice (n = 5–9) and treated them with pentoxifylline for twelve weeks. Results TAC induced a cardiac hypertrophy in VEETKO and WT mice but a reduction of fractional shortening could be detected by echocardiography in VEETKO mice only. Cardiomyocyte diameter was significantly increased by TAC in VEETKO mice only. Pentoxifylline treatment prevented cardiac hypertrophy and reduction of fractional shortening in VEETKO mice but decreased fractional shortening in WT mice. Collagen deposition and number of apoptotic cells remained stable between the groups as did TNF-α, caspase-3 and caspase-8 messenger RNA expression levels. TAC surgery enhanced ANP, BNP and bcl2 expression. Pentoxifylline treatment reduced expression levels of BNP, bcl2 and bax. Conclusions Lack of endothelial ET-1 worsened the impact of TAC-induced pressure overload on cardiac function, indicating the crucial role of ET-1 for normal cardiac function under stress. Moreover, we put in light a TNF-α-independent beneficial effect of pentoxifylline in the VEETKO mice suggesting a therapeutic potential for pentoxifylline in a subpopulation of heart failure patients at higher risk." @default.
• W2056136674 created "2016-06-24" @default.
• W2056136674 creator A5006145523 @default.
• W2056136674 creator A5008726482 @default.
• W2056136674 creator A5030370402 @default.
• W2056136674 creator A5044376527 @default.
• W2056136674 creator A5044700950 @default.
• W2056136674 creator A5046689124 @default.
• W2056136674 creator A5085216868 @default.
• W2056136674 date "2014-02-11" @default.
• W2056136674 modified "2023-09-23" @default.
• W2056136674 title "Vascular Endothelium Derived Endothelin-1 Is Required for Normal Heart Function after Chronic Pressure Overload in Mice" @default.
• W2056136674 cites W18749133 @default.
• W2056136674 cites W1943841898 @default.
• W2056136674 cites W1969352294 @default.
• W2056136674 cites W1970184826 @default.
• W2056136674 cites W1976799893 @default.
• W2056136674 cites W1984235771 @default.
• W2056136674 cites W1990660058 @default.
• W2056136674 cites W1993858973 @default.
• W2056136674 cites W1999011993 @default.
• W2056136674 cites W2001626665 @default.
• W2056136674 cites W2009479213 @default.
• W2056136674 cites W2015882806 @default.
• W2056136674 cites W2016254275 @default.
• W2056136674 cites W2027534438 @default.
• W2056136674 cites W2027588196 @default.
• W2056136674 cites W2031137884 @default.
• W2056136674 cites W2032413810 @default.
• W2056136674 cites W2034813299 @default.
• W2056136674 cites W2035279910 @default.
• W2056136674 cites W2041376120 @default.
• W2056136674 cites W2046879073 @default.
• W2056136674 cites W2052017836 @default.
• W2056136674 cites W2060077704 @default.
• W2056136674 cites W2063311461 @default.
• W2056136674 cites W2064811416 @default.
• W2056136674 cites W2075075037 @default.
• W2056136674 cites W2082499822 @default.
• W2056136674 cites W2082765989 @default.
• W2056136674 cites W2084685244 @default.
• W2056136674 cites W2104450197 @default.
• W2056136674 cites W2105289127 @default.
• W2056136674 cites W2105356761 @default.
• W2056136674 cites W2118527036 @default.
• W2056136674 cites W2118673294 @default.
• W2056136674 cites W2123652686 @default.
• W2056136674 cites W2130900795 @default.
• W2056136674 cites W2138091764 @default.
• W2056136674 cites W2143516414 @default.
• W2056136674 cites W2144935053 @default.
• W2056136674 cites W2145602685 @default.
• W2056136674 cites W2147155927 @default.
• W2056136674 cites W2148511906 @default.
• W2056136674 cites W2152658552 @default.
• W2056136674 cites W2159513257 @default.
• W2056136674 cites W2326836632 @default.
• W2056136674 cites W2398009078 @default.
• W2056136674 doi "https://doi.org/10.1371/journal.pone.0088730" @default.
• W2056136674 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3921186" @default.
• W2056136674 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24523936" @default.
• W2056136674 hasPublicationYear "2014" @default.
• W2056136674 type Work @default.
• W2056136674 sameAs 2056136674 @default.
• W2056136674 citedByCount "19" @default.
• W2056136674 countsByYear W20561366742014 @default.
• W2056136674 countsByYear W20561366742015 @default.
• W2056136674 countsByYear W20561366742016 @default.
• W2056136674 countsByYear W20561366742017 @default.
• W2056136674 countsByYear W20561366742018 @default.
• W2056136674 countsByYear W20561366742019 @default.
• W2056136674 countsByYear W20561366742022 @default.
• W2056136674 countsByYear W20561366742023 @default.
• W2056136674 crossrefType "journal-article" @default.
• W2056136674 hasAuthorship W2056136674A5006145523 @default.
• W2056136674 hasAuthorship W2056136674A5008726482 @default.
• W2056136674 hasAuthorship W2056136674A5030370402 @default.
• W2056136674 hasAuthorship W2056136674A5044376527 @default.
• W2056136674 hasAuthorship W2056136674A5044700950 @default.
• W2056136674 hasAuthorship W2056136674A5046689124 @default.
• W2056136674 hasAuthorship W2056136674A5085216868 @default.
• W2056136674 hasBestOaLocation W20561366741 @default.
• W2056136674 hasConcept C111566952 @default.
• W2056136674 hasConcept C126322002 @default.
• W2056136674 hasConcept C134018914 @default.
• W2056136674 hasConcept C144980905 @default.
• W2056136674 hasConcept C149601957 @default.
• W2056136674 hasConcept C164705383 @default.
• W2056136674 hasConcept C170493617 @default.
• W2056136674 hasConcept C190283241 @default.
• W2056136674 hasConcept C2776992346 @default.
• W2056136674 hasConcept C2778198053 @default.
• W2056136674 hasConcept C2778271984 @default.
• W2056136674 hasConcept C2780404050 @default.
• W2056136674 hasConcept C3018791406 @default.
• W2056136674 hasConcept C55493867 @default.
• W2056136674 hasConcept C71924100 @default.
• W2056136674 hasConcept C86803240 @default.

• next