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• W2056143722 abstract "The cyclin-dependent kinase Cdk5 has attracted a great deal of attention both because of its roles in cell migration and axon patterning, and the extensive data implicating it in adult-onset neurodegeneration in mammals. Both the kinase activity and the biological effects of Cdk5 are absolutely dependent on association with an activating subunit, called p35. We show here that Drosophila lacking the Cdk5 activator, D-p35, display a wide range of defects in embryonic axon patterning. We further show that, while viable and fertile, p35 mutant adults display progressive, age-dependent loss of motor function and have a significantly shortened lifespan." @default.
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• W2056143722 date "2007-05-01" @default.
• W2056143722 modified "2023-09-26" @default.
• W2056143722 title "Drosophila lacking the Cdk5 activator, p35, display defective axon guidance, age-dependent behavioral deficits and reduced lifespan" @default.
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• W2056143722 doi "https://doi.org/10.1016/j.mod.2007.02.002" @default.
• W2056143722 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2045698" @default.
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