Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056160243> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2056160243 abstract "Background: Permanent polymers used in current drug-eluting stent (DES) can trigger inflammatory reactions contributing to increased risk of late thrombosis and rebound restenosis. Optimal polymer selection and the use of completely absorbable polymers are expected to minimize these risks. Aim: To evaluate a novel potentially innately anti-inflammatory, salicylatebased bioabsorbable polymer eluting sirolimus in a clinically relevant animal model. Methods: Four different types of stents (n=36) were implanted in coronary arteries of 12 pigs using QCA to optimize stent apposition: bare metal stents (BMS); salicylic acid/adipic acid bioabsorbable polymer-only coated stents (SA/AA); Cypher stents; and metal stents coated with salicylic acid/adipic acid bioabsorbable polymer containing sirolimus (SA/AA+S). Dose density of sirolimus was 8.3 μg/mm of stent length, with in vitro studies demonstrating elution over 30 days and complete polymer degradation in 4–6 weeks. Animals were terminated at 1 month after angiographic restudy, for histopathologic and histomorphometric analyses. Results: Both SA/AA+S and Cypher stents had significantly lower angiographic % stenosis than BMS and SA/AA polymer-only groups (6±4% and 5±4% vs. 15±7% and 16±5%, respectively, Pb.001). Intimal thickness was lower for SA/AA+S and Cypher than for BMS (0.14±0.06 and 0.13±0.04 vs. 0.23±0.05 mm, respectively, Pb.001). Histologic % area stenosis was also lower for SA/AA+S and Cypher than for BMS (22±7% and 23±6% vs. 33±5%, respectively, Pb.001). The inflammatory reaction to SA/AA and to SA/AA+S was mild, whereas inflammation in BMS and Cypher tended to be more pronounced (P=.072). Conclusions: This study showed favorable vascular compatibility and efficacy of a novel anti-inflammatory salicylate-based biodegradable polymer eluting sirolimus. Since there is a tendency for reduced vessel wall inflammatory response and this polymer is fully absorbable, there may be significant improvement over existing DES to avoid late stent thrombosis." @default.
- W2056160243 created "2016-06-24" @default.
- W2056160243 creator A5014882930 @default.
- W2056160243 creator A5036599235 @default.
- W2056160243 creator A5064923253 @default.
- W2056160243 date "2008-07-01" @default.
- W2056160243 modified "2023-10-02" @default.
- W2056160243 title "Novel anti-inflammatory salicylate-based bioabsorbable drug-eluting polymeric stent coating" @default.
- W2056160243 doi "https://doi.org/10.1016/j.carrev.2008.03.071" @default.
- W2056160243 hasPublicationYear "2008" @default.
- W2056160243 type Work @default.
- W2056160243 sameAs 2056160243 @default.
- W2056160243 citedByCount "1" @default.
- W2056160243 crossrefType "journal-article" @default.
- W2056160243 hasAuthorship W2056160243A5014882930 @default.
- W2056160243 hasAuthorship W2056160243A5036599235 @default.
- W2056160243 hasAuthorship W2056160243A5064923253 @default.
- W2056160243 hasConcept C126322002 @default.
- W2056160243 hasConcept C141071460 @default.
- W2056160243 hasConcept C185592680 @default.
- W2056160243 hasConcept C2777546689 @default.
- W2056160243 hasConcept C2777921159 @default.
- W2056160243 hasConcept C2778221352 @default.
- W2056160243 hasConcept C2778283817 @default.
- W2056160243 hasConcept C2778583881 @default.
- W2056160243 hasConcept C2780007028 @default.
- W2056160243 hasConcept C3019562390 @default.
- W2056160243 hasConcept C55493867 @default.
- W2056160243 hasConcept C71924100 @default.
- W2056160243 hasConceptScore W2056160243C126322002 @default.
- W2056160243 hasConceptScore W2056160243C141071460 @default.
- W2056160243 hasConceptScore W2056160243C185592680 @default.
- W2056160243 hasConceptScore W2056160243C2777546689 @default.
- W2056160243 hasConceptScore W2056160243C2777921159 @default.
- W2056160243 hasConceptScore W2056160243C2778221352 @default.
- W2056160243 hasConceptScore W2056160243C2778283817 @default.
- W2056160243 hasConceptScore W2056160243C2778583881 @default.
- W2056160243 hasConceptScore W2056160243C2780007028 @default.
- W2056160243 hasConceptScore W2056160243C3019562390 @default.
- W2056160243 hasConceptScore W2056160243C55493867 @default.
- W2056160243 hasConceptScore W2056160243C71924100 @default.
- W2056160243 hasLocation W20561602431 @default.
- W2056160243 hasOpenAccess W2056160243 @default.
- W2056160243 hasPrimaryLocation W20561602431 @default.
- W2056160243 hasRelatedWork W149595291 @default.
- W2056160243 hasRelatedWork W1572321976 @default.
- W2056160243 hasRelatedWork W1979311597 @default.
- W2056160243 hasRelatedWork W2009226068 @default.
- W2056160243 hasRelatedWork W2016368598 @default.
- W2056160243 hasRelatedWork W2027159156 @default.
- W2056160243 hasRelatedWork W2053104553 @default.
- W2056160243 hasRelatedWork W2061671710 @default.
- W2056160243 hasRelatedWork W2125291234 @default.
- W2056160243 hasRelatedWork W2169728289 @default.
- W2056160243 hasRelatedWork W2206528516 @default.
- W2056160243 hasRelatedWork W2366521448 @default.
- W2056160243 hasRelatedWork W2387280207 @default.
- W2056160243 hasRelatedWork W2392553743 @default.
- W2056160243 hasRelatedWork W2393886212 @default.
- W2056160243 hasRelatedWork W2408709008 @default.
- W2056160243 hasRelatedWork W2409544618 @default.
- W2056160243 hasRelatedWork W2411939357 @default.
- W2056160243 hasRelatedWork W2969533128 @default.
- W2056160243 hasRelatedWork W2410281542 @default.
- W2056160243 isParatext "false" @default.
- W2056160243 isRetracted "false" @default.
- W2056160243 magId "2056160243" @default.
- W2056160243 workType "article" @default.