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• W2056162564 startingPage "e1002319" @default.
• W2056162564 abstract "Barrier epithelia that are persistently exposed to microbes have evolved potent immune tools to eliminate such pathogens. If mechanisms that control Drosophila systemic responses are well-characterized, the epithelial immune responses remain poorly understood. Here, we performed a genetic dissection of the cascades activated during the immune response of the Drosophila airway epithelium i.e. trachea. We present evidence that bacteria induced-antimicrobial peptide (AMP) production in the trachea is controlled by two signalling cascades. AMP gene transcription is activated by the inducible IMD pathway that acts non-cell autonomously in trachea. This IMD-dependent AMP activation is antagonized by a constitutively active signalling module involving the receptor Toll-8/Tollo, the ligand Spätzle2/DNT1 and Ect-4, the Drosophila ortholog of the human Sterile alpha and HEAT/ARMadillo motif (SARM). Our data show that, in addition to Toll-1 whose function is essential during the systemic immune response, Drosophila relies on another Toll family member to control the immune response in the respiratory epithelium." @default.
• W2056162564 created "2016-06-24" @default.
• W2056162564 creator A5034719003 @default.
• W2056162564 creator A5038490838 @default.
• W2056162564 creator A5063317819 @default.
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• W2056162564 date "2011-10-13" @default.
• W2056162564 modified "2023-10-04" @default.
• W2056162564 title "Toll-8/Tollo Negatively Regulates Antimicrobial Response in the Drosophila Respiratory Epithelium" @default.
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• W2056162564 doi "https://doi.org/10.1371/journal.ppat.1002319" @default.
• W2056162564 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3192845" @default.
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• W2056162564 hasPublicationYear "2011" @default.
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