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• W2056163313 abstract "Abstract Mdm2 is a critical negative regulator of the p53 tumor suppressor and is frequently overexpressed in human cancers. However, reports, including our own studies, suggest that Mdm2 has both p53-dependent and p53-independent functions that contribute to genomic instability and transformation when deregulated. We recently elucidated a p53-independent role for Mdm2 in the regulation of the DNA double-strand break repair response, genomic stability, and transformation through interaction with Nbs1, a member of the Mre11/Rad50/Nbs1 DNA double-strand break repair complex. In light of these findings, targeting Mdm2 in human malignancies may have effects other than activating p53. [Cancer Res 2009;69(5):1697–701]" @default.
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• W2056163313 date "2009-03-01" @default.
• W2056163313 modified "2023-09-23" @default.
• W2056163313 title "Mdm2 Affects Genome Stability Independent of p53" @default.
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• W2056163313 doi "https://doi.org/10.1158/0008-5472.can-08-3732" @default.
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