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- W2056163752 abstract "Abstract Sera from patients with systemic lupus erythematosus were fractionated by sucrose density gradient ultracentrifugation. Individual fractions were assayed for immunoglobulin and for antibody activity to human DNA, to reovirus RNA, and to a DNA:RNA hybrid (deoxythymidylic·riboadenylic acid, dT·rA). Antibodies to dT·rA were distributed in two peaks corresponding to 19S IgM and 7S IgG. Antibodies to DNA were predominantly IgG, whereas antibodies to RNA showed a more variable distribution. IgM antibodies to RNA were quite prominent and in some patients were the only anti-RNA antibodies detected. These results are discussed in relation to genetic and antigenic factors which determine the immunoglobulin class of anti-nucleic acid antibodies." @default.
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- W2056163752 date "1975-05-01" @default.
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- W2056163752 title "IgM and IgG antibodies to DNA, RNA, and DNA:RNA in systemic lupus erythematosus" @default.
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- W2056163752 doi "https://doi.org/10.1016/0090-1229(75)90035-5" @default.
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