Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056166014> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2056166014 endingPage "1593" @default.
- W2056166014 startingPage "1589" @default.
- W2056166014 abstract "We have previously demonstrated the preferential activation of the K-ras gene from the susceptible A/J parent in lung tumors from F1 mouse hybrids. In the present study, the mechanism of this observation is further investigated. Higher levels of expression of A/J K-ras allele were detected in lung adenomas (30 of 30) from the C3A mouse. In addition, three K-ras alleles, designated as susceptible (Ks), intermediate (Ki), or resistant (Kr), were identified by sequence analysis of the second intron of the K-ras gene from 32 strains of mice. These K-ras alleles are associated with differences in mouse lung tumor susceptibility. All Kr alleles have a tandem 37-bp direct repeat (nt 282-355) in the second intron of the K-ras gene. Ks and Ki alleles have only one copy of the 37-bp sequence (nt 282-318). Ks strains have three base variations at nt 288, 296, and 494, and Ki strains have two base variations at nt 288 and 494 in the second intron of the K-ras gene. Differential protein-binding patterns were observed in gel-mobility-shift experiments between the duplicated 37-bp sequence of the Kr allele and the single 37-bp sequence of the Ks and Ki alleles. DNase I footprinting assay revealed protein binding sites in the second intron of the K-ras gene that correspond to the tandem repeat sequences. Our data suggest that higher expression of the A/J allele relative to C3H allele may be responsible for the allele-specific activation of the K-ras gene in lung tumors from F1 hybrid mice." @default.
- W2056166014 created "2016-06-24" @default.
- W2056166014 creator A5048156502 @default.
- W2056166014 creator A5052730281 @default.
- W2056166014 creator A5061594020 @default.
- W2056166014 creator A5067414086 @default.
- W2056166014 creator A5072228402 @default.
- W2056166014 date "1994-02-15" @default.
- W2056166014 modified "2023-09-27" @default.
- W2056166014 title "The second intron of the K-ras gene containsregulatory elements associated with mouse lung tumorsusceptibility." @default.
- W2056166014 cites W1758507682 @default.
- W2056166014 cites W1950706016 @default.
- W2056166014 cites W2000441481 @default.
- W2056166014 cites W2025723633 @default.
- W2056166014 cites W2031935887 @default.
- W2056166014 cites W2038291290 @default.
- W2056166014 cites W2048649566 @default.
- W2056166014 cites W2056823084 @default.
- W2056166014 cites W2069798708 @default.
- W2056166014 cites W2084106399 @default.
- W2056166014 cites W2084914085 @default.
- W2056166014 cites W2089089142 @default.
- W2056166014 cites W2091349388 @default.
- W2056166014 cites W2101619466 @default.
- W2056166014 cites W2118094114 @default.
- W2056166014 cites W2122225626 @default.
- W2056166014 cites W2126865533 @default.
- W2056166014 cites W2131821779 @default.
- W2056166014 cites W2137751470 @default.
- W2056166014 cites W2165857243 @default.
- W2056166014 cites W2258915442 @default.
- W2056166014 cites W2278304192 @default.
- W2056166014 cites W2414609590 @default.
- W2056166014 cites W2414701338 @default.
- W2056166014 cites W2428284707 @default.
- W2056166014 doi "https://doi.org/10.1073/pnas.91.4.1589" @default.
- W2056166014 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/43205" @default.
- W2056166014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8108449" @default.
- W2056166014 hasPublicationYear "1994" @default.
- W2056166014 type Work @default.
- W2056166014 sameAs 2056166014 @default.
- W2056166014 citedByCount "80" @default.
- W2056166014 countsByYear W20561660142012 @default.
- W2056166014 countsByYear W20561660142013 @default.
- W2056166014 countsByYear W20561660142014 @default.
- W2056166014 countsByYear W20561660142015 @default.
- W2056166014 countsByYear W20561660142016 @default.
- W2056166014 countsByYear W20561660142017 @default.
- W2056166014 countsByYear W20561660142018 @default.
- W2056166014 countsByYear W20561660142020 @default.
- W2056166014 crossrefType "journal-article" @default.
- W2056166014 hasAuthorship W2056166014A5048156502 @default.
- W2056166014 hasAuthorship W2056166014A5052730281 @default.
- W2056166014 hasAuthorship W2056166014A5061594020 @default.
- W2056166014 hasAuthorship W2056166014A5067414086 @default.
- W2056166014 hasAuthorship W2056166014A5072228402 @default.
- W2056166014 hasBestOaLocation W20561660142 @default.
- W2056166014 hasConcept C104317684 @default.
- W2056166014 hasConcept C141231307 @default.
- W2056166014 hasConcept C150194340 @default.
- W2056166014 hasConcept C153911025 @default.
- W2056166014 hasConcept C180754005 @default.
- W2056166014 hasConcept C27149982 @default.
- W2056166014 hasConcept C54355233 @default.
- W2056166014 hasConcept C86803240 @default.
- W2056166014 hasConcept C94671646 @default.
- W2056166014 hasConceptScore W2056166014C104317684 @default.
- W2056166014 hasConceptScore W2056166014C141231307 @default.
- W2056166014 hasConceptScore W2056166014C150194340 @default.
- W2056166014 hasConceptScore W2056166014C153911025 @default.
- W2056166014 hasConceptScore W2056166014C180754005 @default.
- W2056166014 hasConceptScore W2056166014C27149982 @default.
- W2056166014 hasConceptScore W2056166014C54355233 @default.
- W2056166014 hasConceptScore W2056166014C86803240 @default.
- W2056166014 hasConceptScore W2056166014C94671646 @default.
- W2056166014 hasIssue "4" @default.
- W2056166014 hasLocation W20561660141 @default.
- W2056166014 hasLocation W20561660142 @default.
- W2056166014 hasLocation W20561660143 @default.
- W2056166014 hasLocation W20561660144 @default.
- W2056166014 hasOpenAccess W2056166014 @default.
- W2056166014 hasPrimaryLocation W20561660141 @default.
- W2056166014 hasRelatedWork W1971010738 @default.
- W2056166014 hasRelatedWork W2009966535 @default.
- W2056166014 hasRelatedWork W2010887132 @default.
- W2056166014 hasRelatedWork W2039352533 @default.
- W2056166014 hasRelatedWork W2041335525 @default.
- W2056166014 hasRelatedWork W2057739827 @default.
- W2056166014 hasRelatedWork W2070922469 @default.
- W2056166014 hasRelatedWork W2081600652 @default.
- W2056166014 hasRelatedWork W2109717569 @default.
- W2056166014 hasRelatedWork W2223919059 @default.
- W2056166014 hasVolume "91" @default.
- W2056166014 isParatext "false" @default.
- W2056166014 isRetracted "false" @default.
- W2056166014 magId "2056166014" @default.
- W2056166014 workType "article" @default.