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• W2056172005 abstract "The pharmacokinetics of intravenously administered clindamycin phosphate was studied in 40 children <1 year of age. Mean peak serum concentrations were 10.92 μg/ml in premature infants <4 weeks of age, 10.45 μg/ml in term infants >4 weeks, and 12.69 μg/ml in term infants <4 weeks of age. Mean trough concentrations were 5.52, 2.8, and 3.03 μg/ml, respectively, in the same groups. Serum half-life was significantly longer (8.68 vs 3.60 hours) in premature compared with term infants <4 weeks of age. Both premature and term infants <4 weeks had significantly decreased clearance when compared with infants >4 weeks (0.294 and 0.678, respectively, vs 1.58 L/hr). Clearance was significantly greater (1.919 vs 0.310 L/hr) and serum half-life less (1.75 vs 7.57 hours) in infants with body weight >3.5 kg. On the basis of these data it is recommended that in infants >4 weeks or >3.5 kg, intravenous clindamycin dosage be 20 mg/kg/day in four divided doses. In premature neonates <4 weeks, the dose should be reduced to 15 mg/kg/day in three divided doses. Term infants >1 week of age may also receive 20 mg/kg/day in four doses. The pharmacokinetics of intravenously administered clindamycin phosphate was studied in 40 children <1 year of age. Mean peak serum concentrations were 10.92 μg/ml in premature infants <4 weeks of age, 10.45 μg/ml in term infants >4 weeks, and 12.69 μg/ml in term infants <4 weeks of age. Mean trough concentrations were 5.52, 2.8, and 3.03 μg/ml, respectively, in the same groups. Serum half-life was significantly longer (8.68 vs 3.60 hours) in premature compared with term infants <4 weeks of age. Both premature and term infants <4 weeks had significantly decreased clearance when compared with infants >4 weeks (0.294 and 0.678, respectively, vs 1.58 L/hr). Clearance was significantly greater (1.919 vs 0.310 L/hr) and serum half-life less (1.75 vs 7.57 hours) in infants with body weight >3.5 kg. On the basis of these data it is recommended that in infants >4 weeks or >3.5 kg, intravenous clindamycin dosage be 20 mg/kg/day in four divided doses. In premature neonates <4 weeks, the dose should be reduced to 15 mg/kg/day in three divided doses. Term infants >1 week of age may also receive 20 mg/kg/day in four doses." @default.
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• W2056172005 title "Pharmacokinetics of clindamycin phosphate in the first year of life" @default.
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• W2056172005 doi "https://doi.org/10.1016/s0022-3476(84)80033-5" @default.
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