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• W2056172893 endingPage "3463" @default.
• W2056172893 startingPage "3456" @default.
• W2056172893 abstract "Multiple myeloma is a monoclonal tumor of plasma cells, and its development is preceded by a premalignant tumor with which it shares genetic abnormalities, including universal dysregulation of the cyclin D/retinoblastoma (cyclin D/RB) pathway. A complex interaction with the BM microenvironment, characterized by activation of osteoclasts and suppression of osteoblasts, leads to lytic bone disease. Intratumor genetic heterogeneity, which occurs in addition to intertumor heterogeneity, contributes to the rapid emergence of drug resistance in high-risk disease. Despite recent therapeutic advances, which have doubled the median survival time, myeloma continues to be a mostly incurable disease. Here we review the current understanding of myeloma pathogenesis and insight into new therapeutic strategies provided by animal models and genetic screens." @default.
• W2056172893 created "2016-06-24" @default.
• W2056172893 creator A5010780079 @default.
• W2056172893 creator A5038546398 @default.
• W2056172893 date "2012-10-01" @default.
• W2056172893 modified "2023-09-30" @default.
• W2056172893 title "Molecular pathogenesis of multiple myeloma and its premalignant precursor" @default.
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• W2056172893 doi "https://doi.org/10.1172/jci61188" @default.
• W2056172893 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3461901" @default.
• W2056172893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23023717" @default.
• W2056172893 hasPublicationYear "2012" @default.
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