Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056190922> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2056190922 abstract "The non-invasive identification of epidermal growth factor receptor (EGFR) mutations is important for the institution of individualized therapy of non-small cell lung cancer (NSCLC). In this study, the feasibility of screening for EGFR exon 19 E746_A750del mutations in circulating DNA from plasma was assessed.Mutant-specific primers with a Taqman probe (MST-PCR) were designed. The ability of this method to accurately detect decreasing concentrations of E746_A750del mutant within a wild type DNA background that mimics the situation of a plasma sample from patients with acquired mutations is verified. To verify the clinical applicability of this method, 55 plasma samples from NSCLC patients were tested, and the sensitivity of MST-PCR was compared to that of direct sequencing.The results showed that MST-PCR could detect 10 to 50 copies/microL of E746_A750del, representing 0.1% of the wild type EGFR allelic population. Among the 55 cases of NSCLC, 10 cases of E746_A750del were detected by MST-PCR, while only 1 case was revealed by direct sequencing.These findings demonstrate that MST-PCR provides superior sensitivity for the detection of the E746_A750del mutation, suggesting its potential application in the noninvasive detection of E746_A750del mutations in plasma samples from NSCLC patients." @default.
- W2056190922 created "2016-06-24" @default.
- W2056190922 creator A5000018805 @default.
- W2056190922 creator A5013484301 @default.
- W2056190922 creator A5028153142 @default.
- W2056190922 creator A5089351331 @default.
- W2056190922 date "2014-01-01" @default.
- W2056190922 modified "2023-10-16" @default.
- W2056190922 title "Non-invasive Detection of EGFR Deletion at Exon 19 in Non-Small Cell Lung Cancer by Real Time Diagnostic" @default.
- W2056190922 doi "https://doi.org/10.7754/clin.lab.2014.140106" @default.
- W2056190922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25291948" @default.
- W2056190922 hasPublicationYear "2014" @default.
- W2056190922 type Work @default.
- W2056190922 sameAs 2056190922 @default.
- W2056190922 citedByCount "3" @default.
- W2056190922 countsByYear W20561909222015 @default.
- W2056190922 countsByYear W20561909222017 @default.
- W2056190922 countsByYear W20561909222019 @default.
- W2056190922 crossrefType "journal-article" @default.
- W2056190922 hasAuthorship W2056190922A5000018805 @default.
- W2056190922 hasAuthorship W2056190922A5013484301 @default.
- W2056190922 hasAuthorship W2056190922A5028153142 @default.
- W2056190922 hasAuthorship W2056190922A5089351331 @default.
- W2056190922 hasConcept C104317684 @default.
- W2056190922 hasConcept C121608353 @default.
- W2056190922 hasConcept C142724271 @default.
- W2056190922 hasConcept C143660080 @default.
- W2056190922 hasConcept C153911025 @default.
- W2056190922 hasConcept C2776256026 @default.
- W2056190922 hasConcept C2779438470 @default.
- W2056190922 hasConcept C2908647359 @default.
- W2056190922 hasConcept C36823959 @default.
- W2056190922 hasConcept C49105822 @default.
- W2056190922 hasConcept C54355233 @default.
- W2056190922 hasConcept C71924100 @default.
- W2056190922 hasConcept C86803240 @default.
- W2056190922 hasConcept C99454951 @default.
- W2056190922 hasConceptScore W2056190922C104317684 @default.
- W2056190922 hasConceptScore W2056190922C121608353 @default.
- W2056190922 hasConceptScore W2056190922C142724271 @default.
- W2056190922 hasConceptScore W2056190922C143660080 @default.
- W2056190922 hasConceptScore W2056190922C153911025 @default.
- W2056190922 hasConceptScore W2056190922C2776256026 @default.
- W2056190922 hasConceptScore W2056190922C2779438470 @default.
- W2056190922 hasConceptScore W2056190922C2908647359 @default.
- W2056190922 hasConceptScore W2056190922C36823959 @default.
- W2056190922 hasConceptScore W2056190922C49105822 @default.
- W2056190922 hasConceptScore W2056190922C54355233 @default.
- W2056190922 hasConceptScore W2056190922C71924100 @default.
- W2056190922 hasConceptScore W2056190922C86803240 @default.
- W2056190922 hasConceptScore W2056190922C99454951 @default.
- W2056190922 hasIssue "09/2014" @default.
- W2056190922 hasLocation W20561909221 @default.
- W2056190922 hasLocation W20561909222 @default.
- W2056190922 hasOpenAccess W2056190922 @default.
- W2056190922 hasPrimaryLocation W20561909221 @default.
- W2056190922 hasRelatedWork W1533538298 @default.
- W2056190922 hasRelatedWork W1870702796 @default.
- W2056190922 hasRelatedWork W2160636733 @default.
- W2056190922 hasRelatedWork W2350207578 @default.
- W2056190922 hasRelatedWork W2369505912 @default.
- W2056190922 hasRelatedWork W2378899322 @default.
- W2056190922 hasRelatedWork W2383054771 @default.
- W2056190922 hasRelatedWork W2392225573 @default.
- W2056190922 hasRelatedWork W4313472722 @default.
- W2056190922 hasRelatedWork W4320928914 @default.
- W2056190922 hasVolume "60" @default.
- W2056190922 isParatext "false" @default.
- W2056190922 isRetracted "false" @default.
- W2056190922 magId "2056190922" @default.
- W2056190922 workType "article" @default.