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- W2056200812 abstract "A MUC1-based vaccine was used in a preclinical model of colon cancer. The trial was conducted in a MUC1-tolerant immune competent host injected with MC38 colon cancer cells expressing MUC1. The vaccine included: MHC class I-restricted MUC1 peptides, MHC class II-restricted pan-helper-peptide, unmethylated CpG oligodeoxynucleotide, and granulocyte macrophage-colony stimulating factor. Immunization was successful in breaking MUC1 self-tolerance, and in eliciting a robust anti-tumor response. The vaccine stimulated IFN-γ-producing CD4+ helper and CD8+ cytotoxic T cells against MUC1 and other undefined MC38 tumor antigens. In the prophylactic setting, immunization caused complete rejection of tumor cells, while in the therapeutic regimen, tumor burden was significantly reduced." @default.
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- W2056200812 date "2007-02-01" @default.
- W2056200812 modified "2023-09-26" @default.
- W2056200812 title "MUC1-specific immune therapy generates a strong anti-tumor response in a MUC1-tolerant colon cancer model" @default.
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- W2056200812 doi "https://doi.org/10.1016/j.vaccine.2006.11.007" @default.
- W2056200812 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1810513" @default.
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