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• W2056201283 abstract "<i>Background:</i> Abnormal body composition, with low muscle mass and increased fat mass, as well as short adult stature are common features in Prader-Willi syndrome (PWS), as in growth hormone (GH) deficiency. <i>Methods:</i> We followed a cohort of 22 genetically verified patients with PWS from the start of GH (Genotropin®) treatment at the median age of 6.9 years (4.9–11.3) to near-adult height at 18.1 years (16.4–21.2). The patients were treated with a median GH dose of 0.03 mg/kg/day (0.02–0.03) for a median duration of 10.2 years (6.9–11.5). <i>Results:</i> All patients reached near-adult height within midparental height median –0.5 SDS (–1.4 to 0.7) and 0.9 SDS (0.1–1.9) for girls and boys, respectively. The body composition improved but did not normalize. Only 7 of the 22 patients were reported to be in puberty. None of the patients were reported to be on sex hormone substitution which might contribute to not reaching a normal body composition. No serious side effects were reported when the caloric intake was controlled to maintain an appropriate body weight. <i>Conclusion:</i> GH treatment in children with Prader-Wili syndrome normalizes adult height and improves body composition." @default.
• W2056201283 created "2016-06-24" @default.
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• W2056201283 date "2008-01-01" @default.
• W2056201283 modified "2023-09-25" @default.
• W2056201283 title "Growth Hormone Treatment Completely Normalizes Adult Height and Improves Body Composition in Prader-Willi Syndrome: Experience from KIGS (Pfizer International Growth Database)" @default.
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• W2056201283 doi "https://doi.org/10.1159/000145019" @default.
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