Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056208727> ?p ?o ?g. }
- W2056208727 endingPage "343" @default.
- W2056208727 startingPage "339" @default.
- W2056208727 abstract "The importance of stress-activated protein/mitogen-activated protein kinase (SAP/MAPK) pathway signalling (involving c-Jun-N-terminal kinase [JNK], extracellular signal-regulated kinase [ERK] and p38 kinase) in normal cellular proliferation, differentiation and programmed cell death has led to significant recent advances in our understanding of the role of SAP/MAPK signaling in inflammatory disorders such as arthritis and cardiovascular disease, cancer, and pulmonary and neurogenerative diseases. The discovery that several natural products such as resveratrol, tangeretin and ligustilide non-specifically inhibit SAP/MAPK signalling in vitro should now be logically extended to studies designed to determine how agents in these natural products regulate SAP/MAPK pathways in animal models of disease. A new generation of small-molecule SAP/MAPK inhibitors that demonstrate increasing specificity for each of the JNK, ERK and p38 kinase isoforms has shown promise in animal studies and could eventually prove effective for treating human diseases. Several of these compounds are already being tested in human subjects to assess their oral bioavailability, pharmacokinetics and toxicity." @default.
- W2056208727 created "2016-06-24" @default.
- W2056208727 creator A5037419784 @default.
- W2056208727 date "2007-06-01" @default.
- W2056208727 modified "2023-10-03" @default.
- W2056208727 title "Inhibitors of stress-activated protein/mitogen-activated protein kinase pathways" @default.
- W2056208727 cites W1491779959 @default.
- W2056208727 cites W1933537883 @default.
- W2056208727 cites W1966582134 @default.
- W2056208727 cites W1966894313 @default.
- W2056208727 cites W1991667983 @default.
- W2056208727 cites W1992843538 @default.
- W2056208727 cites W1998599963 @default.
- W2056208727 cites W2000096354 @default.
- W2056208727 cites W2000598142 @default.
- W2056208727 cites W2003578093 @default.
- W2056208727 cites W2016906514 @default.
- W2056208727 cites W2021321634 @default.
- W2056208727 cites W2021405916 @default.
- W2056208727 cites W2021681883 @default.
- W2056208727 cites W2025010847 @default.
- W2056208727 cites W2025655898 @default.
- W2056208727 cites W2039099155 @default.
- W2056208727 cites W2042464158 @default.
- W2056208727 cites W2042612710 @default.
- W2056208727 cites W2050422354 @default.
- W2056208727 cites W2080686146 @default.
- W2056208727 cites W2082562728 @default.
- W2056208727 cites W2087379913 @default.
- W2056208727 cites W2094982088 @default.
- W2056208727 cites W2095169768 @default.
- W2056208727 cites W2102261996 @default.
- W2056208727 cites W2114502358 @default.
- W2056208727 cites W2118033606 @default.
- W2056208727 cites W2118072506 @default.
- W2056208727 cites W2118529503 @default.
- W2056208727 cites W2140765540 @default.
- W2056208727 cites W2144980016 @default.
- W2056208727 cites W2146397794 @default.
- W2056208727 cites W2147389584 @default.
- W2056208727 cites W2153142245 @default.
- W2056208727 cites W2154666745 @default.
- W2056208727 cites W2157698752 @default.
- W2056208727 cites W2161809170 @default.
- W2056208727 cites W2170050915 @default.
- W2056208727 cites W2406519984 @default.
- W2056208727 doi "https://doi.org/10.1016/j.coph.2006.11.012" @default.
- W2056208727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17398158" @default.
- W2056208727 hasPublicationYear "2007" @default.
- W2056208727 type Work @default.
- W2056208727 sameAs 2056208727 @default.
- W2056208727 citedByCount "55" @default.
- W2056208727 countsByYear W20562087272012 @default.
- W2056208727 countsByYear W20562087272013 @default.
- W2056208727 countsByYear W20562087272014 @default.
- W2056208727 countsByYear W20562087272015 @default.
- W2056208727 countsByYear W20562087272017 @default.
- W2056208727 countsByYear W20562087272023 @default.
- W2056208727 crossrefType "journal-article" @default.
- W2056208727 hasAuthorship W2056208727A5037419784 @default.
- W2056208727 hasConcept C124160383 @default.
- W2056208727 hasConcept C132149769 @default.
- W2056208727 hasConcept C137361374 @default.
- W2056208727 hasConcept C184235292 @default.
- W2056208727 hasConcept C502942594 @default.
- W2056208727 hasConcept C51551487 @default.
- W2056208727 hasConcept C57074206 @default.
- W2056208727 hasConcept C62478195 @default.
- W2056208727 hasConcept C86803240 @default.
- W2056208727 hasConcept C90934575 @default.
- W2056208727 hasConcept C95444343 @default.
- W2056208727 hasConcept C97029542 @default.
- W2056208727 hasConcept C98274493 @default.
- W2056208727 hasConceptScore W2056208727C124160383 @default.
- W2056208727 hasConceptScore W2056208727C132149769 @default.
- W2056208727 hasConceptScore W2056208727C137361374 @default.
- W2056208727 hasConceptScore W2056208727C184235292 @default.
- W2056208727 hasConceptScore W2056208727C502942594 @default.
- W2056208727 hasConceptScore W2056208727C51551487 @default.
- W2056208727 hasConceptScore W2056208727C57074206 @default.
- W2056208727 hasConceptScore W2056208727C62478195 @default.
- W2056208727 hasConceptScore W2056208727C86803240 @default.
- W2056208727 hasConceptScore W2056208727C90934575 @default.
- W2056208727 hasConceptScore W2056208727C95444343 @default.
- W2056208727 hasConceptScore W2056208727C97029542 @default.
- W2056208727 hasConceptScore W2056208727C98274493 @default.
- W2056208727 hasIssue "3" @default.
- W2056208727 hasLocation W20562087271 @default.
- W2056208727 hasLocation W20562087272 @default.
- W2056208727 hasOpenAccess W2056208727 @default.
- W2056208727 hasPrimaryLocation W20562087271 @default.
- W2056208727 hasRelatedWork W1811191752 @default.
- W2056208727 hasRelatedWork W1976385326 @default.
- W2056208727 hasRelatedWork W2004726042 @default.
- W2056208727 hasRelatedWork W2007355797 @default.
- W2056208727 hasRelatedWork W2011123717 @default.
- W2056208727 hasRelatedWork W2056208727 @default.
- W2056208727 hasRelatedWork W2097226779 @default.