FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056215313> ?p ?o ?g. }

• W2056215313 endingPage "677.e9" @default.
• W2056215313 startingPage "677.e1" @default.
• W2056215313 abstract "The human ascending aorta becomes markedly prone to rupture and dissection at a diameter of 6 cm. The mechanical substrate for this malignant behavior is unknown. This investigation applied engineering analysis to human ascending aortic aneurysms and compared their structural characteristics with those of normal aortas.We measured the mechanical characteristics of the aorta by direct epiaortic echocardiography at the time of surgery in 33 patients with ascending aortic aneurysm undergoing aortic replacement and in 20 control patients with normal aortas undergoing coronary artery bypass grafting. Six parameters were measured in all patients: aortic diameter in systole and diastole, aortic wall thickness in systole and diastole, and blood pressure in systole and diastole. These were used to calculate mechanical characteristics of the aorta from standard equations. Aortic distensibility reflects the elastic qualities of the aorta. Aortic wall stress reflects the disrupting force experienced within the aortic wall. Incremental elastic modulus indicates loss of elasticity reserve.Aortic distensibility falls to extremely low levels as aortic dimension rises toward 6 cm (3.02 mm Hg(-1) for small aortas versus 1.45 mm Hg(-1) for aortas larger than 5 cm, P < .05). Aortic wall stress rises to 157.8 kPa for the aneurysmal aorta, compared with 92.5 kPa for normal aortas. For 6-cm aortas at pressures of 200 mm Hg or more, wall stress rises to 857 kPa, nearly exceeding the known maximal tensile strength of human aneurysmal aortic wall. Incremental elastic modulus deteriorates (1.93 +/- 0.88 MPa vs 1.18 +/- 0.21 MPa, P < .05) in aneurysmal aortas relative to that in normal aortas.The mechanical properties of the aneurysmal aorta deteriorate dramatically as the aorta enlarges, reaching critical levels associated with rupture by a diameter of 6 cm. This mechanical deterioration provides an explanation in engineering terms for the malignant clinical behavior (rupture and dissection) of the aorta at these dimensions. This work adds to our fundamental understanding of the biology of aortic aneurysms and promises to permit future application of engineering measurements to supplement aneurysm size in clinical decision making in aneurysmal disease." @default.
• W2056215313 created "2016-06-24" @default.
• W2056215313 creator A5030305242 @default.
• W2056215313 creator A5038668174 @default.
• W2056215313 creator A5038710502 @default.
• W2056215313 creator A5045425733 @default.
• W2056215313 creator A5051029640 @default.
• W2056215313 creator A5090408695 @default.
• W2056215313 date "2005-09-01" @default.
• W2056215313 modified "2023-10-13" @default.
• W2056215313 title "Mechanical deterioration underlies malignant behavior of aneurysmal human ascending aorta" @default.
• W2056215313 cites W1967407909 @default.
• W2056215313 cites W1982035017 @default.
• W2056215313 cites W2009154640 @default.
• W2056215313 cites W2015908017 @default.
• W2056215313 cites W2015915459 @default.
• W2056215313 cites W2020360951 @default.
• W2056215313 cites W2081488602 @default.
• W2056215313 cites W2093860004 @default.
• W2056215313 cites W2146052423 @default.
• W2056215313 cites W2152239418 @default.
• W2056215313 cites W3143448550 @default.
• W2056215313 cites W4239965812 @default.
• W2056215313 cites W4376567326 @default.
• W2056215313 doi "https://doi.org/10.1016/j.jtcvs.2005.02.052" @default.
• W2056215313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16153912" @default.
• W2056215313 hasPublicationYear "2005" @default.
• W2056215313 type Work @default.
• W2056215313 sameAs 2056215313 @default.
• W2056215313 citedByCount "144" @default.
• W2056215313 countsByYear W20562153132012 @default.
• W2056215313 countsByYear W20562153132013 @default.
• W2056215313 countsByYear W20562153132014 @default.
• W2056215313 countsByYear W20562153132015 @default.
• W2056215313 countsByYear W20562153132016 @default.
• W2056215313 countsByYear W20562153132017 @default.
• W2056215313 countsByYear W20562153132018 @default.
• W2056215313 countsByYear W20562153132019 @default.
• W2056215313 countsByYear W20562153132020 @default.
• W2056215313 countsByYear W20562153132021 @default.
• W2056215313 countsByYear W20562153132022 @default.
• W2056215313 countsByYear W20562153132023 @default.
• W2056215313 crossrefType "journal-article" @default.
• W2056215313 hasAuthorship W2056215313A5030305242 @default.
• W2056215313 hasAuthorship W2056215313A5038668174 @default.
• W2056215313 hasAuthorship W2056215313A5038710502 @default.
• W2056215313 hasAuthorship W2056215313A5045425733 @default.
• W2056215313 hasAuthorship W2056215313A5051029640 @default.
• W2056215313 hasAuthorship W2056215313A5090408695 @default.
• W2056215313 hasBestOaLocation W20562153131 @default.
• W2056215313 hasConcept C126322002 @default.
• W2056215313 hasConcept C141071460 @default.
• W2056215313 hasConcept C164705383 @default.
• W2056215313 hasConcept C169554166 @default.
• W2056215313 hasConcept C2776098176 @default.
• W2056215313 hasConcept C2777323849 @default.
• W2056215313 hasConcept C2778249958 @default.
• W2056215313 hasConcept C2779980429 @default.
• W2056215313 hasConcept C2779993142 @default.
• W2056215313 hasConcept C57900726 @default.
• W2056215313 hasConcept C71924100 @default.
• W2056215313 hasConcept C84393581 @default.
• W2056215313 hasConceptScore W2056215313C126322002 @default.
• W2056215313 hasConceptScore W2056215313C141071460 @default.
• W2056215313 hasConceptScore W2056215313C164705383 @default.
• W2056215313 hasConceptScore W2056215313C169554166 @default.
• W2056215313 hasConceptScore W2056215313C2776098176 @default.
• W2056215313 hasConceptScore W2056215313C2777323849 @default.
• W2056215313 hasConceptScore W2056215313C2778249958 @default.
• W2056215313 hasConceptScore W2056215313C2779980429 @default.
• W2056215313 hasConceptScore W2056215313C2779993142 @default.
• W2056215313 hasConceptScore W2056215313C57900726 @default.
• W2056215313 hasConceptScore W2056215313C71924100 @default.
• W2056215313 hasConceptScore W2056215313C84393581 @default.
• W2056215313 hasIssue "3" @default.
• W2056215313 hasLocation W20562153131 @default.
• W2056215313 hasLocation W20562153132 @default.
• W2056215313 hasOpenAccess W2056215313 @default.
• W2056215313 hasPrimaryLocation W20562153131 @default.
• W2056215313 hasRelatedWork W2030353550 @default.
• W2056215313 hasRelatedWork W2052723448 @default.
• W2056215313 hasRelatedWork W2132584388 @default.
• W2056215313 hasRelatedWork W2164159143 @default.
• W2056215313 hasRelatedWork W2312780947 @default.
• W2056215313 hasRelatedWork W2342485342 @default.
• W2056215313 hasRelatedWork W2352745255 @default.
• W2056215313 hasRelatedWork W2568471411 @default.
• W2056215313 hasRelatedWork W3028960828 @default.
• W2056215313 hasRelatedWork W4210662164 @default.
• W2056215313 hasVolume "130" @default.
• W2056215313 isParatext "false" @default.
• W2056215313 isRetracted "false" @default.
• W2056215313 magId "2056215313" @default.
• W2056215313 workType "article" @default.