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• W2056220619 abstract "Determinar si un valor de NGAL >150 ng/ml es una buena prueba diagnóstica para detectar precozmente disfunción renal aguda (DRA) en el paciente crítico. Estudio prospectivo, observacional, de cohorte. Unidad de cuidados intensivos y de cirugía cardíaca del Servicio de Medicina Intensiva del Hospital Germans Trias i Pujol. Los pacientes ingresados en el Servicio de Medicina Intensiva los días designados en el estudio. Análisis sanguíneo de la creatinina sérica determinada desde siete días antes del día de inicio del estudio, y diariamente durante cuatro semanas. Determinación de NGAL mediante prueba de orina, en muestra congelada, con el analizador ARCHITECT (Abbott diagnostics) por inmunoanálisis determinado el día de inicio del estudio y dos veces a la semana durante cuatro semanas, análisis de la estancia y mortalidad. Se obtuvieron 529 muestras de NGAL de 46 pacientes. El 37% de los pacientes presentaron un valor de NGAL >150 ng/ml. La sensibilidad de la prueba para diagnosticar DRA fue del 69%, la especificidad fue del 75,7%. Sin embargo, el valor predictivo positivo fue del 53%, lo cual significa que el 47% de los pacientes con NGAL alto no desarrollaron DRA. Un NGAL >150 mg/dL se asoció de manera significativa a un SOFA más alto y a una estancia más larga en UCI. La mortalidad de los pacientes con NGAL elevado fue del 58,8%. Un NGAL >150 ng/mL no parece ser una excelente prueba para detectar DRA en el paciente crítico pero si que se asocia con un peor pronóstico. To determine if NGAL value exceeding 150 ng/mL is a good diagnostic test for acute renal failure in critically ill patients. Prospective, observational cohort. Intensive Care Unit and Cardiac Surgery Intensive Care Service at Hospital Germans Trias I Pujol. Patients admitted to the Intensive Care department the Designated days in the studio. Analysis of serum creatinine blood given from 7 days prior to the start of the study, and daily during 4 weeks and by determination of NGAL urine test in frozen sample, analyzer ARCHITECT (Abbott Diagnostics) determined by immunoassay the day baseline and 2 times a week for 4 weeks, analysis of the stay and mortality. A total of 529 NGAL samples were obtained from 46 patients. 37% of patients had a value of NGAL >150 ng/mL. The Sensivity of the test to diagnose acute renal failure was 69%, Specifity was 75,7%. However, the Positive Predictive Test Value was 53%, which means that 47% of patients with high NGAL did not develop AKI. A NGAL >150 mg/dL was associated with a significantly higher SOFA and a longer stay in the ICU. The mortality of patients with elevated NGAL was 58.8%. A NGAL >150 ng/mL does not seem to be an excellent test for AKI in critically ill patients but is associated with a worse prognosis." @default.
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• W2056220619 date "2014-04-01" @default.
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• W2056220619 title "Análisis de la lipocalina asociada a la gelatinasa de neutrófilos en el paciente crítico" @default.
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• W2056220619 doi "https://doi.org/10.1016/j.medin.2013.03.014" @default.
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