FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056248768> ?p ?o ?g. }

• W2056248768 endingPage "e66091" @default.
• W2056248768 startingPage "e66091" @default.
• W2056248768 abstract "Sperm acquire motility and fertility capacity during epididymal transit, under the control of androgens and sympathetic innervations. It is already known that the acceleration of epididymal sperm transit time can lead to lower sperm quality. In a previous work we showed that rats exposed to the anorexigen sibutramine, a non-selective serotonin-norepinephrine reuptake inhibitor, presented faster sperm transit time, lower epididymal sperm reserves and potentiation of the tension of epididymal duct to norepinephrine exposed acutely in vitro to sibutramine. In the present work we aimed to further investigate pharmacological mechanisms involved in these alterations and the impact on rat sperm quality. For this, adult male Wistar rats were treated with sibutramine (10 mg/kg/day) or vehicle for 30 days. Sibutramine decreased final body, seminal vesicle, ventral prostate and epididymal weights, as well as sperm transit time in the epididymal cauda. On the contrary of the in vitro pharmacological assays, in which sibutramine was added directly to the bath containing strips of distal epididymal cauda, the ductal tension was not altered after in vivo sub-chronic exposure to sibutramine. However, there is pharmacological evidence that the endogenous epididymal norepinephrine reserves were reduced in these animals. It was also shown that the decrease in prostate weight can be related to increased tension developed of the gland, due to sibutramine sympathomimetic effects. In addition, our results showed reduced sperm quality after in utero artificial insemination, a more sensitive procedure to assess fertility in rodents. The epididymal norepinephrine depletion exerted by sibutramine, associated with decreases in sperm transit time, quantity and quality, leading to reduced fertility in this experimental model, reinforces the concerns about the possible impact on fertility of man taking sibutramine as well as other non-selective serotonin-norepinephrine reuptake inhibitors, especially considering the lower reproductive efficiency of humans compared to males of other species." @default.
• W2056248768 created "2016-06-24" @default.
• W2056248768 creator A5012421956 @default.
• W2056248768 creator A5015296324 @default.
• W2056248768 creator A5024129764 @default.
• W2056248768 creator A5036965760 @default.
• W2056248768 creator A5051582662 @default.
• W2056248768 creator A5055126451 @default.
• W2056248768 creator A5059356540 @default.
• W2056248768 creator A5073973702 @default.
• W2056248768 creator A5075113231 @default.
• W2056248768 creator A5088977333 @default.
• W2056248768 date "2013-06-12" @default.
• W2056248768 modified "2023-10-16" @default.
• W2056248768 title "Slimmer or Fertile? Pharmacological Mechanisms Involved in Reduced Sperm Quality and Fertility in Rats Exposed to the Anorexigen Sibutramine" @default.
• W2056248768 cites W1965371962 @default.
• W2056248768 cites W1970846822 @default.
• W2056248768 cites W1972039019 @default.
• W2056248768 cites W1973941781 @default.
• W2056248768 cites W1997312032 @default.
• W2056248768 cites W2001403436 @default.
• W2056248768 cites W2011399384 @default.
• W2056248768 cites W2018541977 @default.
• W2056248768 cites W2028532495 @default.
• W2056248768 cites W2038823716 @default.
• W2056248768 cites W2039472232 @default.
• W2056248768 cites W2050332191 @default.
• W2056248768 cites W2050933076 @default.
• W2056248768 cites W2054371063 @default.
• W2056248768 cites W2057288427 @default.
• W2056248768 cites W2061777582 @default.
• W2056248768 cites W2068849159 @default.
• W2056248768 cites W2071988467 @default.
• W2056248768 cites W2074046229 @default.
• W2056248768 cites W2074190054 @default.
• W2056248768 cites W2074419619 @default.
• W2056248768 cites W2084164893 @default.
• W2056248768 cites W2084292926 @default.
• W2056248768 cites W2087324712 @default.
• W2056248768 cites W2096946565 @default.
• W2056248768 cites W2102447197 @default.
• W2056248768 cites W2109099082 @default.
• W2056248768 cites W2115259899 @default.
• W2056248768 cites W2116106170 @default.
• W2056248768 cites W2118802990 @default.
• W2056248768 cites W2126189268 @default.
• W2056248768 cites W2149350777 @default.
• W2056248768 cites W2152368658 @default.
• W2056248768 cites W2163661255 @default.
• W2056248768 cites W2163687543 @default.
• W2056248768 cites W2163840073 @default.
• W2056248768 cites W2164194934 @default.
• W2056248768 cites W2164231447 @default.
• W2056248768 cites W2237726082 @default.
• W2056248768 cites W2411633347 @default.
• W2056248768 cites W2494477556 @default.
• W2056248768 cites W3021714837 @default.
• W2056248768 cites W1982269465 @default.
• W2056248768 doi "https://doi.org/10.1371/journal.pone.0066091" @default.
• W2056248768 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3680400" @default.
• W2056248768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23776614" @default.
• W2056248768 hasPublicationYear "2013" @default.
• W2056248768 type Work @default.
• W2056248768 sameAs 2056248768 @default.
• W2056248768 citedByCount "21" @default.
• W2056248768 countsByYear W20562487682013 @default.
• W2056248768 countsByYear W20562487682014 @default.
• W2056248768 countsByYear W20562487682015 @default.
• W2056248768 countsByYear W20562487682016 @default.
• W2056248768 countsByYear W20562487682017 @default.
• W2056248768 countsByYear W20562487682018 @default.
• W2056248768 countsByYear W20562487682019 @default.
• W2056248768 countsByYear W20562487682020 @default.
• W2056248768 countsByYear W20562487682021 @default.
• W2056248768 countsByYear W20562487682022 @default.
• W2056248768 countsByYear W20562487682023 @default.
• W2056248768 crossrefType "journal-article" @default.
• W2056248768 hasAuthorship W2056248768A5012421956 @default.
• W2056248768 hasAuthorship W2056248768A5015296324 @default.
• W2056248768 hasAuthorship W2056248768A5024129764 @default.
• W2056248768 hasAuthorship W2056248768A5036965760 @default.
• W2056248768 hasAuthorship W2056248768A5051582662 @default.
• W2056248768 hasAuthorship W2056248768A5055126451 @default.
• W2056248768 hasAuthorship W2056248768A5059356540 @default.
• W2056248768 hasAuthorship W2056248768A5073973702 @default.
• W2056248768 hasAuthorship W2056248768A5075113231 @default.
• W2056248768 hasAuthorship W2056248768A5088977333 @default.
• W2056248768 hasBestOaLocation W20562487681 @default.
• W2056248768 hasConcept C126322002 @default.
• W2056248768 hasConcept C134018914 @default.
• W2056248768 hasConcept C16685009 @default.
• W2056248768 hasConcept C2777632594 @default.
• W2056248768 hasConcept C2777646958 @default.
• W2056248768 hasConcept C2781087480 @default.
• W2056248768 hasConcept C2781254305 @default.
• W2056248768 hasConcept C511355011 @default.
• W2056248768 hasConcept C544821477 @default.
• W2056248768 hasConcept C71924100 @default.

• next