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• W2056257769 endingPage "1001" @default.
• W2056257769 startingPage "987" @default.
• W2056257769 abstract "torso encodes a receptor tyrosine kinase (torso) required for anterior and posterior terminal development of the Drosophila embryo. Injecting eggs with in vitro synthesized torso mRNAs revealed that torso activation is governed by an extracellular molecule, presumably the torso ligand, produced at terminal regions of the egg during early embryogenesis. In the absence of torso, the ligand shows no apparent localization, indicating that it is diffusible and normally bound by an excess of torso receptor at the egg poles. Mutant ligand-binding torso proteins can suppress telson formation in a dominant negative manner, suggesting that the ligand is limited in amount. Analysis of torso mutations indicates that torso functions as a tyrosine kinase and that gain-of-function mutations causing ligand-independent activation are located in the extracellular domain." @default.
• W2056257769 created "2016-06-24" @default.
• W2056257769 creator A5001248753 @default.
• W2056257769 creator A5072765144 @default.
• W2056257769 date "1992-12-01" @default.
• W2056257769 modified "2023-10-16" @default.
• W2056257769 title "Torso receptor activity is regulated by a diffusible ligand produced at the extracellular terminal regions of the Drosophila egg" @default.
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• W2056257769 doi "https://doi.org/10.1016/0092-8674(92)90394-r" @default.
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