FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056272012> ?p ?o ?g. }

• W2056272012 abstract "BACKGROUND. Mutations in two major susceptibility genes, BRCAI and BRCA2, account for most hereditary breast carcinoma (HBC). METHODS. BRCAI and BRCA2 genotype-phenotype associations are reviewed with special emphasis on pathologic characteristics. Tumor spectra in families, prognosis phenotype, and molecular biologic correlates with phenotype are also explored. RESULTS. BRCAI is an estrogen-inducable cell cycle-associated protein with anti-proliferation and tumor suppressor function. Less is known about BRCA2 protein but it has some similarities to BRCA1. Release of cells from BRCA1 control through germline mutations gives rise to genetically evolved breast carcinomas with a highly distinctive and correspondent proliferator phenotype featuring aneuploidy, high S-phase fraction, high mitotic grade, and medullary carcinomas. BRCA1 HBCs also show a deficit of ductal carcinoma in situ and invasive lobular, tubular, tubulolobular, and cribriform (tubular-lobular group [TLG]) carcinomas. In contrast, the BRCA2 HBC phenotype, although less well determined and possibly more heterogeneous, appears to lack the more extensive BRCA1 proliferator characteristics but may have excess TLG carcinomas. Despite their adverse pathoprognostic features, BRCAI HBCs have paradoxically better disease free survivals than non-BRCA1 HBCs, but data are not yet clear whether this effect can be attributed to BRCA2 HBC generally. Larger studies are needed to assess potential heterogeneity. CONCLUSIONS. Although the phenotypes are presently imperfectly resolved, early studies indicate differences between BRCAI and BRCA2 HBC." @default.
• W2056272012 created "2016-06-24" @default.
• W2056272012 creator A5010712504 @default.
• W2056272012 creator A5029960276 @default.
• W2056272012 creator A5036424514 @default.
• W2056272012 creator A5051859145 @default.
• W2056272012 creator A5078971738 @default.
• W2056272012 creator A5088516335 @default.
• W2056272012 date "1997-08-01" @default.
• W2056272012 modified "2023-10-04" @default.
• W2056272012 title "BRCA1 and BRCA2 hereditary breast carcinoma phenotypes" @default.
• W2056272012 cites W1964108360 @default.
• W2056272012 cites W1967155906 @default.
• W2056272012 cites W1969238951 @default.
• W2056272012 cites W1970379686 @default.
• W2056272012 cites W1973690102 @default.
• W2056272012 cites W1974567887 @default.
• W2056272012 cites W1974731601 @default.
• W2056272012 cites W1978669977 @default.
• W2056272012 cites W1980450624 @default.
• W2056272012 cites W1982553868 @default.
• W2056272012 cites W1983700019 @default.
• W2056272012 cites W1986812747 @default.
• W2056272012 cites W1988000039 @default.
• W2056272012 cites W1988515793 @default.
• W2056272012 cites W1988848776 @default.
• W2056272012 cites W1989834813 @default.
• W2056272012 cites W1991555006 @default.
• W2056272012 cites W1993342975 @default.
• W2056272012 cites W1996144710 @default.
• W2056272012 cites W1998204845 @default.
• W2056272012 cites W1999349307 @default.
• W2056272012 cites W2000437208 @default.
• W2056272012 cites W2001826602 @default.
• W2056272012 cites W2002119787 @default.
• W2056272012 cites W2005542290 @default.
• W2056272012 cites W2009759387 @default.
• W2056272012 cites W2016760769 @default.
• W2056272012 cites W2019738273 @default.
• W2056272012 cites W2022205756 @default.
• W2056272012 cites W2030093162 @default.
• W2056272012 cites W2036485264 @default.
• W2056272012 cites W2036546668 @default.
• W2056272012 cites W2037954444 @default.
• W2056272012 cites W2038703904 @default.
• W2056272012 cites W2043739672 @default.
• W2056272012 cites W2048226595 @default.
• W2056272012 cites W2048867718 @default.
• W2056272012 cites W2054605948 @default.
• W2056272012 cites W2055294712 @default.
• W2056272012 cites W2058064521 @default.
• W2056272012 cites W2064594479 @default.
• W2056272012 cites W2064937521 @default.
• W2056272012 cites W2065777930 @default.
• W2056272012 cites W2068588019 @default.
• W2056272012 cites W2069881315 @default.
• W2056272012 cites W2071446951 @default.
• W2056272012 cites W2074998890 @default.
• W2056272012 cites W2079388655 @default.
• W2056272012 cites W2082158979 @default.
• W2056272012 cites W2084147994 @default.
• W2056272012 cites W2086199722 @default.
• W2056272012 cites W2089140716 @default.
• W2056272012 cites W2089514388 @default.
• W2056272012 cites W2090740451 @default.
• W2056272012 cites W2102491373 @default.
• W2056272012 cites W2109465247 @default.
• W2056272012 cites W2111703821 @default.
• W2056272012 cites W2116856068 @default.
• W2056272012 cites W2121009435 @default.
• W2056272012 cites W2151308486 @default.
• W2056272012 cites W2153579158 @default.
• W2056272012 cites W2159168998 @default.
• W2056272012 cites W2235146920 @default.
• W2056272012 cites W2329417450 @default.
• W2056272012 cites W2441089400 @default.
• W2056272012 cites W4246344301 @default.
• W2056272012 cites W4297432809 @default.
• W2056272012 doi "https://doi.org/10.1002/(sici)1097-0142(19970801)80:3+<543::aid-cncr4>3.0.co;2-a" @default.
• W2056272012 hasPublicationYear "1997" @default.
• W2056272012 type Work @default.
• W2056272012 sameAs 2056272012 @default.
• W2056272012 citedByCount "47" @default.
• W2056272012 countsByYear W20562720122014 @default.
• W2056272012 countsByYear W20562720122018 @default.
• W2056272012 countsByYear W20562720122019 @default.
• W2056272012 crossrefType "journal-article" @default.
• W2056272012 hasAuthorship W2056272012A5010712504 @default.
• W2056272012 hasAuthorship W2056272012A5029960276 @default.
• W2056272012 hasAuthorship W2056272012A5036424514 @default.
• W2056272012 hasAuthorship W2056272012A5051859145 @default.
• W2056272012 hasAuthorship W2056272012A5078971738 @default.
• W2056272012 hasAuthorship W2056272012A5088516335 @default.
• W2056272012 hasBestOaLocation W20562720121 @default.
• W2056272012 hasConcept C104317684 @default.
• W2056272012 hasConcept C109825262 @default.
• W2056272012 hasConcept C127716648 @default.
• W2056272012 hasConcept C142724271 @default.
• W2056272012 hasConcept C2777546739 @default.
• W2056272012 hasConcept C2779672484 @default.

• next