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- W2056274920 abstract "The activity of single, physiologically identified neurones has been recorded both extra- and intracellularly in the 6th and 7th lumbar segments of the pentobarbitoneanesthetized cat. In the majority of dorsal horn neurones studied (laminae 4 and 5 of Rexed) microiontophoretically applied synthetic substance P and the active fragment, substance P (4–11), were found to cause a slow and prolonged increase of the spontaneous firing rate and/or an enhancement ofL-glutamate induced activity. Intracellular studies revealed that substance P caused a reversible depolarization of both dorsal horn neurones and motoneurones without a detectable alteration of the membrane resistance, antidromic action potential or postsynaptic potentials. These results are compatible with a possible role of substance P in sensory transmission in the spinal cord of the cat." @default.
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- W2056274920 date "1979-04-01" @default.
- W2056274920 modified "2023-09-23" @default.
- W2056274920 title "Effects of substance P on neurones in the dorsal horn of the spinal cord of the cat" @default.
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- W2056274920 doi "https://doi.org/10.1016/0006-8993(79)90213-0" @default.
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