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• W2056284429 abstract "We have synthesized the tetradecamer GAGCXGATAACAAG containing a part of the sequence of the lactose operator. A guanine base in the sequence is replaced by the adduct of the carcinogen 2-acetylaminofluorene with guanine. Under the standard conditions of de-protection, the fluorene moiety is lost, leaving behind a guanine oxidation product. New conditions of de-protection have been developed which allow the isolation of an oligonucleotide containing the adduct of 2-aminofluorene with guanine. The presence of the aminofluorene adduct greatly increases retention on reverse phase chromatography and produces a unique pattern of sequencing bands." @default.
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• W2056284429 date "1983-01-01" @default.
• W2056284429 modified "2023-09-24" @default.
• W2056284429 title "Site-specific modification of the lactose operator with acetylaminofluorene" @default.
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• W2056284429 doi "https://doi.org/10.1093/nar/11.15.5093" @default.
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