FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056284911> ?p ?o ?g. }

• W2056284911 endingPage "180" @default.
• W2056284911 startingPage "175" @default.
• W2056284911 abstract "Clinical and biological features have recognized prognostic significance in acute myeloid leukemia (AML). To evaluate the interaction of these variables and weighted effect on treatment outcome, prognostic variables from 96 previously untreated patients were analyzed for association with expression of the MDR1 gene product P-glycoprotein (Pgp), and effect on response to induction chemotherapy, progression-free survival and overall survival. Multivariate relationships were analyzed using six prognostic variables, including age, cytogenetic pattern, gender, CD34+ surface phenotype, AML type (de novo versus secondary) and Pgp. Univariate comparisons indicate that Pgp (P = 0.0001), cytogenetic pattern (P = 0.0004) and a CD34+ phenotype (P = 0.0005) are predictive of primary treatment failure, whereas Pgp (P = 0.0001) had the greatest predictive value in multivariate analysis. Only cytogenetic pattern retained prognostic significance (P = 0.0143) for response to induction therapy after adjustment for Pgp. Although all variables except gender were associated with Pgp, specimens harboring the favorable karyotypic abnormalities t(15;17), t(8;21) and inv(16) exclusively lacked Pgp expression. In a multivariate model, both Pgp and cytogenetic pattern predicted response and overall survival, whereas secondary AML and cytogenetic pattern influenced remission duration. These findings indicate that cytogenetic pattern has prognostic relevance that is independent of Pgp, and implies the presence of undefined biological mechanisms affecting chemotherapy resistance." @default.
• W2056284911 created "2016-06-24" @default.
• W2056284911 creator A5014401132 @default.
• W2056284911 creator A5026752543 @default.
• W2056284911 creator A5042984313 @default.
• W2056284911 creator A5065716888 @default.
• W2056284911 creator A5067155826 @default.
• W2056284911 creator A5071127912 @default.
• W2056284911 creator A5088363388 @default.
• W2056284911 date "1996-02-01" @default.
• W2056284911 modified "2023-10-18" @default.
• W2056284911 title "Cytogenetics and P-glycoprotein (PGP) are independent predictors of treatment outcome in acute myeloid leukemia (AML)" @default.
• W2056284911 cites W1723032639 @default.
• W2056284911 cites W2000838340 @default.
• W2056284911 cites W2028521588 @default.
• W2056284911 cites W2031186545 @default.
• W2056284911 cites W2043201907 @default.
• W2056284911 cites W2053450804 @default.
• W2056284911 cites W2087348472 @default.
• W2056284911 cites W2165846604 @default.
• W2056284911 cites W2168070336 @default.
• W2056284911 cites W225277523 @default.
• W2056284911 cites W2270961873 @default.
• W2056284911 cites W3041047318 @default.
• W2056284911 cites W329750643 @default.
• W2056284911 cites W4244049791 @default.
• W2056284911 doi "https://doi.org/10.1016/0145-2126(95)00134-4" @default.
• W2056284911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8628017" @default.
• W2056284911 hasPublicationYear "1996" @default.
• W2056284911 type Work @default.
• W2056284911 sameAs 2056284911 @default.
• W2056284911 citedByCount "61" @default.
• W2056284911 countsByYear W20562849112012 @default.
• W2056284911 countsByYear W20562849112013 @default.
• W2056284911 countsByYear W20562849112014 @default.
• W2056284911 countsByYear W20562849112015 @default.
• W2056284911 countsByYear W20562849112016 @default.
• W2056284911 countsByYear W20562849112019 @default.
• W2056284911 countsByYear W20562849112020 @default.
• W2056284911 crossrefType "journal-article" @default.
• W2056284911 hasAuthorship W2056284911A5014401132 @default.
• W2056284911 hasAuthorship W2056284911A5026752543 @default.
• W2056284911 hasAuthorship W2056284911A5042984313 @default.
• W2056284911 hasAuthorship W2056284911A5065716888 @default.
• W2056284911 hasAuthorship W2056284911A5067155826 @default.
• W2056284911 hasAuthorship W2056284911A5071127912 @default.
• W2056284911 hasAuthorship W2056284911A5088363388 @default.
• W2056284911 hasConcept C104317684 @default.
• W2056284911 hasConcept C10515644 @default.
• W2056284911 hasConcept C114851261 @default.
• W2056284911 hasConcept C126322002 @default.
• W2056284911 hasConcept C133936738 @default.
• W2056284911 hasConcept C143998085 @default.
• W2056284911 hasConcept C144301174 @default.
• W2056284911 hasConcept C164465091 @default.
• W2056284911 hasConcept C174475383 @default.
• W2056284911 hasConcept C203014093 @default.
• W2056284911 hasConcept C2776611710 @default.
• W2056284911 hasConcept C2776694085 @default.
• W2056284911 hasConcept C2778461978 @default.
• W2056284911 hasConcept C2778707650 @default.
• W2056284911 hasConcept C2778729363 @default.
• W2056284911 hasConcept C30481170 @default.
• W2056284911 hasConcept C38180746 @default.
• W2056284911 hasConcept C50382708 @default.
• W2056284911 hasConcept C54355233 @default.
• W2056284911 hasConcept C63363279 @default.
• W2056284911 hasConcept C71924100 @default.
• W2056284911 hasConcept C86803240 @default.
• W2056284911 hasConceptScore W2056284911C104317684 @default.
• W2056284911 hasConceptScore W2056284911C10515644 @default.
• W2056284911 hasConceptScore W2056284911C114851261 @default.
• W2056284911 hasConceptScore W2056284911C126322002 @default.
• W2056284911 hasConceptScore W2056284911C133936738 @default.
• W2056284911 hasConceptScore W2056284911C143998085 @default.
• W2056284911 hasConceptScore W2056284911C144301174 @default.
• W2056284911 hasConceptScore W2056284911C164465091 @default.
• W2056284911 hasConceptScore W2056284911C174475383 @default.
• W2056284911 hasConceptScore W2056284911C203014093 @default.
• W2056284911 hasConceptScore W2056284911C2776611710 @default.
• W2056284911 hasConceptScore W2056284911C2776694085 @default.
• W2056284911 hasConceptScore W2056284911C2778461978 @default.
• W2056284911 hasConceptScore W2056284911C2778707650 @default.
• W2056284911 hasConceptScore W2056284911C2778729363 @default.
• W2056284911 hasConceptScore W2056284911C30481170 @default.
• W2056284911 hasConceptScore W2056284911C38180746 @default.
• W2056284911 hasConceptScore W2056284911C50382708 @default.
• W2056284911 hasConceptScore W2056284911C54355233 @default.
• W2056284911 hasConceptScore W2056284911C63363279 @default.
• W2056284911 hasConceptScore W2056284911C71924100 @default.
• W2056284911 hasConceptScore W2056284911C86803240 @default.
• W2056284911 hasIssue "2" @default.
• W2056284911 hasLocation W20562849111 @default.
• W2056284911 hasLocation W20562849112 @default.
• W2056284911 hasOpenAccess W2056284911 @default.
• W2056284911 hasPrimaryLocation W20562849111 @default.
• W2056284911 hasRelatedWork W1998995214 @default.
• W2056284911 hasRelatedWork W2013111243 @default.

• next