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• W2056285013 abstract "The effects of intramitochondrial Ca2+ on the activities of the Ca2+-sensitive intramitochondrial enzymes, (i) pyruvate dehydrogenase (PDH) phosphate phosphatase, and (ii) oxoglutarate dehydrogenase (OGDH), were investigated in intact rat liver mitochondria by measuring (i) the amount of active PDH (PDHa) and (ii) the rate of decarboxylation of alpha-[l-14C]oxoglutarate (at non-saturating [oxoglutarate]), at different concentrations of extramitochondrial Ca2+. In the presence of Na+ and Mg2+, both PDH and OGDH could be activated by increases in extramitochondrial [Ca2+] within the expected physiological range (0.05-5 microM). When liver mitochondria were prepared from rats treated with adrenaline, and then incubated in Na-free media containing EGTA, both PDH and OGDH activities were found to be enhanced. Evidence is presented that the activation of these enzymes by adrenaline is brought about by a mechanism involving increases in intramitochondrial [Ca2+]." @default.
• W2056285013 created "2016-06-24" @default.
• W2056285013 creator A5090970978 @default.
• W2056285013 date "1985-01-28" @default.
• W2056285013 modified "2023-09-26" @default.
• W2056285013 title "Evidence that adrenaline activates key oxidative enzymes in rat liver by increasing intramitochondrial [Ca²⁺]" @default.
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• W2056285013 doi "https://doi.org/10.1016/0014-5793(85)81082-6" @default.
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