FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056285452> ?p ?o ?g. }

• W2056285452 endingPage "176" @default.
• W2056285452 startingPage "169" @default.
• W2056285452 abstract "The goal of this study was to develop a gene delivery imaging system that targets hepatocytes to help diagnose and treat various liver diseases. To this end, we prepared superparamagnetic iron oxide nanoparticles (SPIO)-loaded with water-soluble chitosan (WSC)-linoleic acid (LA) nanoparticles (SCLNs) that formed gene complexes capable of localizing specifically to hepatocytes. We confirmed that (99m)Tc-labeled SCLNs delivered into mice via intravenous injection accumulated mainly in the liver using nuclear and magnetic resonance imaging. SCLN/enhanced green fluorescence protein (pEGFP) complexes were also successfully formed and were characterized with a gel retardation assay. SCLN/pEGFP complexes were transfected into primary hepatocytes, where GFP expression was observed in the cytoplasm. In addition, the injection of the gene complexes into mice resulted in significantly increased expression of GFP in hepatocytes in vivo. Furthermore, gene silencing was effectively achieved by administration of gene complexes loaded with specific siRNAs. In conclusion, our results indicate that the SCLNs have the potential to be useful for hepatocyte-targeted imaging and effective gene delivery into hepatocytes." @default.
• W2056285452 created "2016-06-24" @default.
• W2056285452 creator A5001737851 @default.
• W2056285452 creator A5006339259 @default.
• W2056285452 creator A5011091703 @default.
• W2056285452 creator A5039469890 @default.
• W2056285452 creator A5045566016 @default.
• W2056285452 creator A5079729400 @default.
• W2056285452 creator A5082078967 @default.
• W2056285452 creator A5086691038 @default.
• W2056285452 creator A5002173683 @default.
• W2056285452 date "2009-05-08" @default.
• W2056285452 modified "2023-10-09" @default.
• W2056285452 title "Superparamagnetic iron oxide nanoparticles-loaded chitosan-linoleic acid nanoparticles as an effective hepatocyte-targeted gene delivery system" @default.
• W2056285452 cites W1490154674 @default.
• W2056285452 cites W1963201296 @default.
• W2056285452 cites W1969497292 @default.
• W2056285452 cites W1976062460 @default.
• W2056285452 cites W1991755374 @default.
• W2056285452 cites W1993236239 @default.
• W2056285452 cites W2033639000 @default.
• W2056285452 cites W2038984754 @default.
• W2056285452 cites W2039418035 @default.
• W2056285452 cites W2039985275 @default.
• W2056285452 cites W2063981332 @default.
• W2056285452 cites W2067395158 @default.
• W2056285452 cites W2081197509 @default.
• W2056285452 cites W2082641947 @default.
• W2056285452 cites W2093648430 @default.
• W2056285452 cites W2093717599 @default.
• W2056285452 cites W2110921202 @default.
• W2056285452 cites W2115187647 @default.
• W2056285452 cites W2157195361 @default.
• W2056285452 cites W2161859610 @default.
• W2056285452 cites W2166926604 @default.
• W2056285452 cites W2275426013 @default.
• W2056285452 cites W2341207229 @default.
• W2056285452 cites W2403534389 @default.
• W2056285452 cites W29247090 @default.
• W2056285452 doi "https://doi.org/10.1016/j.ijpharm.2009.01.009" @default.
• W2056285452 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19429277" @default.
• W2056285452 hasPublicationYear "2009" @default.
• W2056285452 type Work @default.
• W2056285452 sameAs 2056285452 @default.
• W2056285452 citedByCount "65" @default.
• W2056285452 countsByYear W20562854522012 @default.
• W2056285452 countsByYear W20562854522013 @default.
• W2056285452 countsByYear W20562854522014 @default.
• W2056285452 countsByYear W20562854522015 @default.
• W2056285452 countsByYear W20562854522016 @default.
• W2056285452 countsByYear W20562854522017 @default.
• W2056285452 countsByYear W20562854522018 @default.
• W2056285452 countsByYear W20562854522019 @default.
• W2056285452 countsByYear W20562854522020 @default.
• W2056285452 countsByYear W20562854522021 @default.
• W2056285452 countsByYear W20562854522023 @default.
• W2056285452 crossrefType "journal-article" @default.
• W2056285452 hasAuthorship W2056285452A5001737851 @default.
• W2056285452 hasAuthorship W2056285452A5002173683 @default.
• W2056285452 hasAuthorship W2056285452A5006339259 @default.
• W2056285452 hasAuthorship W2056285452A5011091703 @default.
• W2056285452 hasAuthorship W2056285452A5039469890 @default.
• W2056285452 hasAuthorship W2056285452A5045566016 @default.
• W2056285452 hasAuthorship W2056285452A5079729400 @default.
• W2056285452 hasAuthorship W2056285452A5082078967 @default.
• W2056285452 hasAuthorship W2056285452A5086691038 @default.
• W2056285452 hasConcept C104317684 @default.
• W2056285452 hasConcept C111599444 @default.
• W2056285452 hasConcept C119056186 @default.
• W2056285452 hasConcept C12554922 @default.
• W2056285452 hasConcept C135983454 @default.
• W2056285452 hasConcept C142613039 @default.
• W2056285452 hasConcept C150194340 @default.
• W2056285452 hasConcept C150903083 @default.
• W2056285452 hasConcept C153911025 @default.
• W2056285452 hasConcept C185592680 @default.
• W2056285452 hasConcept C202751555 @default.
• W2056285452 hasConcept C207001950 @default.
• W2056285452 hasConcept C2776200302 @default.
• W2056285452 hasConcept C2779732960 @default.
• W2056285452 hasConcept C54009773 @default.
• W2056285452 hasConcept C55493867 @default.
• W2056285452 hasConcept C86803240 @default.
• W2056285452 hasConceptScore W2056285452C104317684 @default.
• W2056285452 hasConceptScore W2056285452C111599444 @default.
• W2056285452 hasConceptScore W2056285452C119056186 @default.
• W2056285452 hasConceptScore W2056285452C12554922 @default.
• W2056285452 hasConceptScore W2056285452C135983454 @default.
• W2056285452 hasConceptScore W2056285452C142613039 @default.
• W2056285452 hasConceptScore W2056285452C150194340 @default.
• W2056285452 hasConceptScore W2056285452C150903083 @default.
• W2056285452 hasConceptScore W2056285452C153911025 @default.
• W2056285452 hasConceptScore W2056285452C185592680 @default.
• W2056285452 hasConceptScore W2056285452C202751555 @default.
• W2056285452 hasConceptScore W2056285452C207001950 @default.
• W2056285452 hasConceptScore W2056285452C2776200302 @default.
• W2056285452 hasConceptScore W2056285452C2779732960 @default.
• W2056285452 hasConceptScore W2056285452C54009773 @default.

• next