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• W2056285665 abstract "In a study of patients with high-risk DCIS for whom margin widths were less than 1 mm after breast conservation surgery followed by postoperative radiation therapy (RT), Silverstein et al. reported an 8-year ipsilateral breast recurrence probability of 30%, with approximately 80% of recurrence developing within 3 years. This retrospective study included the various RT schedules. Only a few prospective studies have evaluated the role of postoperative RT for only high-risk DCIS. The present prospective study aimed to evaluate the effectiveness of postoperative RT which included whole breast irradiation followed by boost irradiation in patients with high-risk DCIS. We conducted a multi-center phase II study (Japanese Radiation Oncology Study Group: JROSG 05-5) to evaluate the effectiveness of postoperative RT including tangential whole breast irradiation (50 Gy/25 fractions) followed by boost irradiation (10 Gy/5 fractions) using electron beams for patients with high-risk DCIS. A patient was eligible if they (1) had DCIS without an invasive carcinoma component, (2) were between 20 and 80 years of age, (3) were diagnosed as having involved margins or margin widths not more than 1 mm after pathological evaluation using 5 mm thickness specimens, (4) refused re-resection, (5) had a performance status 0−2, and (6) provided written informed consent. The primary endpoint was the ipsilateral breast recurrence rate (IBR), and secondary endpoints were overall survival (OS), relapse-free survival (RFS), recurrence patterns, and adverse events. Thirty-seven patients from 12 institutions were enrolled from January 2007 through May 2009. Median follow-up time was 45 months (range, 27-64 months), median age was 52 years (range, 33-78 years), and median pathological tumor size was 2.5 cm (range, 0.3-8.5 cm). Twenty-one patients had close margins, and sixteen patients had involved margins. Fourteen patients received adjuvant hormonal therapy. Four-year IBR, OS and RFS rates were 3% (95% CI, 0-20), 97% (95% CI, 82-100), and 94% (95% CI, 77-99), respectively. One patient with close margins developed local recurrence after 39 months. She was subjected to a salvage mastectomy, and the pathological diagnosis was DCIS without an invasive component. One patient died due to colon cancer after 28 months, without breast cancer recurrence. No recurrence was identified in regional lymph nodes or distant sites, and no severe adverse events were found. These preliminary results suggest that this RT schedule could be promising for patients with high-risk DCIS. A longer follow-up time is required, however, to make any definitive conclusions." @default.
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• W2056285665 date "2013-10-01" @default.
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• W2056285665 title "Preliminary Results From a Multicenter Prospective Study (JROSG 05-5) on Postoperative Radiation Therapy for Patients With High-Risk Ductal Carcinoma In Situ (DCIS) With Involved Margins or Margin Widths Not More Than 1 mm" @default.
• W2056285665 doi "https://doi.org/10.1016/j.ijrobp.2013.06.535" @default.
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