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• W2056291435 startingPage "630" @default.
• W2056291435 abstract "In order to perform their designated functions, proteins require precise subcellular localizations. For cell-surface proteins, such as receptors and channels, they are able to transduce signals only when properly targeted to the cell membrane. Calreticulin is a multi-functional chaperone protein involved in protein folding, maturation, and trafficking. However, evidence has been accumulating that calreticulin can also negatively regulate the surface expression of certain receptors and channels. In these instances, depletion of calreticulin enhances cell-surface expression and function. In this review, we discuss the role of calreticulin with a focus on its negative effects on the expression of cell-surface proteins." @default.
• W2056291435 created "2016-06-24" @default.
• W2056291435 creator A5071058478 @default.
• W2056291435 creator A5075433733 @default.
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• W2056291435 date "2014-09-16" @default.
• W2056291435 modified "2023-09-27" @default.
• W2056291435 title "Calreticulin: Roles in Cell-Surface Protein Expression" @default.
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• W2056291435 doi "https://doi.org/10.3390/membranes4030630" @default.
• W2056291435 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4194052" @default.
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• W2056291435 hasPublicationYear "2014" @default.
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