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- W2056296054 abstract "(S)-Mephenytoin is metabolized by CYP2C19. The purpose of this study was to examine availability of phenotyping of poor metabolizers (PMs) of (S)-mephenytoin by polymerase chain reaction(PCR)/restriction enzyme genotyping of CYP2C19 in a Japanese population. We genotyped 217 unrelated healthy Japanese for functionally defective allelwm1es, CYP2C19m 1 and CYP2C19m2. The frequencies of the wild type(wm1) and CYP2C19ml were 0.726 and 0.274, and the wild type(wm2) and CYP2C19m2 were 0.892 and 0.108 respectively. Although the observed numbers of three genotypes were very similar to those estimated according to the Hardy-Weinberg equilibrium for each defect, CYP2C19m2 was not detected in ml homozygotes, and CYP2C19ml was not detected in ml homozygotes. Two defects were inherited separately in four families indicating CYP2C19ml and m2 segregate independently at the same gene locus. Based on these data, we calculated the haplotype frequencies of wm1-wm2, CYP2C19ml-wra2 and xvml-CYP2C19rn2 to be 0.618, 0.274 and 0.108 respectively. Frequencies of homozygotes for CYP2C19ml and CYP2C19m2 and compound heterozygotes associated with the PM phenotype, were calculated to be 7.5, 1.2 and 5.9% respectively. In total, 14.6% of Japanese are estimated to be PMs. No significant difference was observed between the frequencies of PMs calculated from our results and that identified by urinary S/R ratio (18%) (p>0.05, x2=0.545,/d=l). Our data indicate that Japanese PMs of (S)-mephenytoin could be identified by PCR-based genotyping of CYP2C19." @default.
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- W2056296054 title "Evidence that poor metabolizers of (S)-mephenytoin could be identified by haplotypes of CYP2C19 in Japanese" @default.
- W2056296054 doi "https://doi.org/10.1097/00008571-199606000-00011" @default.
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