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- W2056296871 abstract "This study is a continuation of investigations of the metabolism of peptides by the rat nasal mucosa, and methods to inhibit metabolism. LH-RH3–10 was rapidly metabolized by aminopeptidases when perfused through the isolated rat nasal cavity. Metabolism was almost completely inhibited by co-perfusing a very low concentration of boroleucine, an aminopeptidase inhibitor. LH-RH3–10 is different from peptides previously evaluated in similar studies, in that non-polar amino acids are adjacent to the site of peptidase cleavage. This study shows that such peptides are metabolized by nasal aminopeptidases, and that metabolism can be inhibited by boroleucine." @default.
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- W2056296871 date "1994-04-25" @default.
- W2056296871 modified "2023-09-25" @default.
- W2056296871 title "Nasal mucosal metabolism of an LH-RH fragment and inhibition with boroleucine" @default.
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- W2056296871 doi "https://doi.org/10.1016/0378-5173(94)90229-1" @default.
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