FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056315356> ?p ?o ?g. }

• W2056315356 endingPage "912" @default.
• W2056315356 startingPage "904" @default.
• W2056315356 abstract "Single nucleotide polymorphisms (SNPs) near 7 loci have been associated with liver function tests or with liver steatosis by magnetic resonance spectroscopy. In this study we aim to test whether these SNPs influence the risk of histologically-confirmed nonalcoholic fatty liver disease (NAFLD). We tested the association of histologic NAFLD with SNPs at 7 loci in 592 cases of European ancestry from the Nonalcoholic Steatohepatitis Clinical Research Network and 1405 ancestry-matched controls. The G allele of rs738409 in PNPLA3 was associated with increased odds of histologic NAFLD (odds ratio [OR] = 3.26, 95% confidence intervals [CI] = 2.11-7.21; P = 3.6 × 10−43). In a case only analysis of G allele of rs738409 in PNPLA3 was associated with a decreased risk of zone 3 centered steatosis (OR = 0.46, 95% CI = 0.36-0.58; P = 5.15 × 10−11). We did not observe any association of this variant with body mass index, triglyceride levels, high- and low-density lipoprotein levels, or diabetes (P > 0.05). None of the variants at the other 6 loci were associated with NAFLD. Conclusion: Genetic variation at PNPLA3 confers a markedly increased risk of increasingly severe histological features of NAFLD, without a strong effect on metabolic syndrome component traits. (HEPATOLOGY 2010)" @default.
• W2056315356 created "2016-06-24" @default.
• W2056315356 creator A5001552586 @default.
• W2056315356 creator A5004013405 @default.
• W2056315356 creator A5028606588 @default.
• W2056315356 creator A5033617328 @default.
• W2056315356 creator A5056419338 @default.
• W2056315356 date "2010-05-18" @default.
• W2056315356 modified "2023-10-16" @default.
• W2056315356 title "<i>PNPLA3</i>variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease" @default.
• W2056315356 cites W1964338619 @default.
• W2056315356 cites W1977088306 @default.
• W2056315356 cites W1978215768 @default.
• W2056315356 cites W2013654496 @default.
• W2056315356 cites W2014848994 @default.
• W2056315356 cites W2017511982 @default.
• W2056315356 cites W2019048359 @default.
• W2056315356 cites W2026818183 @default.
• W2056315356 cites W2054153086 @default.
• W2056315356 cites W2054571656 @default.
• W2056315356 cites W2062549773 @default.
• W2056315356 cites W2067740038 @default.
• W2056315356 cites W2091226975 @default.
• W2056315356 cites W2098591455 @default.
• W2056315356 cites W2105281057 @default.
• W2056315356 cites W2106272645 @default.
• W2056315356 cites W2113743121 @default.
• W2056315356 cites W2117980841 @default.
• W2056315356 cites W2119049139 @default.
• W2056315356 cites W2129150286 @default.
• W2056315356 cites W2136078375 @default.
• W2056315356 cites W2149791927 @default.
• W2056315356 cites W2157752701 @default.
• W2056315356 cites W2161633633 @default.
• W2056315356 cites W2166431807 @default.
• W2056315356 cites W2278793656 @default.
• W2056315356 cites W2911747611 @default.
• W2056315356 cites W4232753943 @default.
• W2056315356 cites W4365808674 @default.
• W2056315356 doi "https://doi.org/10.1002/hep.23768" @default.
• W2056315356 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3070300" @default.
• W2056315356 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20648472" @default.
• W2056315356 hasPublicationYear "2010" @default.
• W2056315356 type Work @default.
• W2056315356 sameAs 2056315356 @default.
• W2056315356 citedByCount "324" @default.
• W2056315356 countsByYear W20563153562012 @default.
• W2056315356 countsByYear W20563153562013 @default.
• W2056315356 countsByYear W20563153562014 @default.
• W2056315356 countsByYear W20563153562015 @default.
• W2056315356 countsByYear W20563153562016 @default.
• W2056315356 countsByYear W20563153562017 @default.
• W2056315356 countsByYear W20563153562018 @default.
• W2056315356 countsByYear W20563153562019 @default.
• W2056315356 countsByYear W20563153562020 @default.
• W2056315356 countsByYear W20563153562021 @default.
• W2056315356 countsByYear W20563153562022 @default.
• W2056315356 countsByYear W20563153562023 @default.
• W2056315356 crossrefType "journal-article" @default.
• W2056315356 hasAuthorship W2056315356A5001552586 @default.
• W2056315356 hasAuthorship W2056315356A5004013405 @default.
• W2056315356 hasAuthorship W2056315356A5028606588 @default.
• W2056315356 hasAuthorship W2056315356A5033617328 @default.
• W2056315356 hasAuthorship W2056315356A5056419338 @default.
• W2056315356 hasBestOaLocation W20563153561 @default.
• W2056315356 hasConcept C104317684 @default.
• W2056315356 hasConcept C126322002 @default.
• W2056315356 hasConcept C134018914 @default.
• W2056315356 hasConcept C135763542 @default.
• W2056315356 hasConcept C142724271 @default.
• W2056315356 hasConcept C153209595 @default.
• W2056315356 hasConcept C156957248 @default.
• W2056315356 hasConcept C180754005 @default.
• W2056315356 hasConcept C2776175330 @default.
• W2056315356 hasConcept C2776954865 @default.
• W2056315356 hasConcept C2778772119 @default.
• W2056315356 hasConcept C2779134260 @default.
• W2056315356 hasConcept C2780578515 @default.
• W2056315356 hasConcept C41260117 @default.
• W2056315356 hasConcept C511355011 @default.
• W2056315356 hasConcept C54355233 @default.
• W2056315356 hasConcept C71924100 @default.
• W2056315356 hasConcept C86803240 @default.
• W2056315356 hasConcept C90924648 @default.
• W2056315356 hasConceptScore W2056315356C104317684 @default.
• W2056315356 hasConceptScore W2056315356C126322002 @default.
• W2056315356 hasConceptScore W2056315356C134018914 @default.
• W2056315356 hasConceptScore W2056315356C135763542 @default.
• W2056315356 hasConceptScore W2056315356C142724271 @default.
• W2056315356 hasConceptScore W2056315356C153209595 @default.
• W2056315356 hasConceptScore W2056315356C156957248 @default.
• W2056315356 hasConceptScore W2056315356C180754005 @default.
• W2056315356 hasConceptScore W2056315356C2776175330 @default.
• W2056315356 hasConceptScore W2056315356C2776954865 @default.
• W2056315356 hasConceptScore W2056315356C2778772119 @default.
• W2056315356 hasConceptScore W2056315356C2779134260 @default.
• W2056315356 hasConceptScore W2056315356C2780578515 @default.
• W2056315356 hasConceptScore W2056315356C41260117 @default.

• next