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- W2056343312 abstract "Brainstem death results in the irreversible loss of the capacity for consciousness and spontaneous respiration. In the UK, brainstem death is equivalent to somatic death and allows for the withdrawal of futile treatments and provides the potential for heart-beating organ donation. The diagnosis is made clinically with strict pre-conditions and exclusions. Pathophysiological responses to brainstem death mean that intensive support must be given to the donor, to ensure adequate organ perfusion to prevent asystole before donation can occur. A major predictive determinant in organ transplantation is the ischaemic time from cessation of cardiac output in the host, until restoration of circulation in the recipient. In particular, the warm ischaemic time from loss of perfusion until flushing and cooling with preservative solution is crucial. With heart-beating, brainstem dead donors, this can be kept to a minimum. More recently, improved preservation techniques and better assessment of organ function have enabled transplant teams to procure kidneys, livers, lungs and pancreases from asystolic donors. These individuals have suffered a catastrophic brain insult, do not fulfil the criteria for brainstem death, but have their treatment withdrawn on the basis of futility. Kidneys taken from these controlled non-heart-beating organ donors often show delayed graft function in the recipient and can require ongoing renal replacement therapy. The results at 5 years, however, are equivalent to those kidneys taken from heart-beating donors who maintain their cardiac output until the point of donation." @default.
- W2056343312 created "2016-06-24" @default.
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- W2056343312 date "2006-06-01" @default.
- W2056343312 modified "2023-09-26" @default.
- W2056343312 title "Brainstem death and the management of the organ donor" @default.
- W2056343312 cites W2115141358 @default.
- W2056343312 doi "https://doi.org/10.1383/anes.2006.7.6.212" @default.
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