FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056351808> ?p ?o ?g. }

• W2056351808 endingPage "1163" @default.
• W2056351808 startingPage "1155" @default.
• W2056351808 abstract "Allosteric modulation refers to the concept that proteins could exist in multiple conformational states and that binding of allosteric ligands alters the energy barriers or isomerization coefficients between various states. In the context of ligand gated ion channels such as nicotinic acetylcholine receptors (nAChRs), it implies that endogenous ligand acetylcholine binds at the orthosteric site, and that molecules that bind elsewhere on the nAChR subunit(s) acts via allosteric interactions. For example, studies with the homomeric alpha7 nAChRs indicate that such ligand interactions can be well described by an allosteric model, and that positive allosteric effectors can affect energy transitions by (i) predominantly affecting the peak current response (Type I profile) or, (ii) both peak current responses and time course of agonist-evoked response (Type II profile). The recent discovery of chemically heterogeneous group of molecules capable of differentially modifying nAChR properties without interacting at the ligand binding site illustrates the adequacy of the allosteric model to predict functional consequences. In this review, we outline general principles of the allosteric concept and summarize the profiles of novel compounds that are emerging as allosteric modulators at the alpha7 and alpha4beta2 nAChR subtypes." @default.
• W2056351808 created "2016-06-24" @default.
• W2056351808 creator A5044940190 @default.
• W2056351808 creator A5063992837 @default.
• W2056351808 date "2007-10-01" @default.
• W2056351808 modified "2023-10-01" @default.
• W2056351808 title "Allosteric modulation of nicotinic acetylcholine receptors" @default.
• W2056351808 cites W120892147 @default.
• W2056351808 cites W1637207518 @default.
• W2056351808 cites W1756214999 @default.
• W2056351808 cites W1785917080 @default.
• W2056351808 cites W1788430178 @default.
• W2056351808 cites W1900806927 @default.
• W2056351808 cites W1959467500 @default.
• W2056351808 cites W1964737820 @default.
• W2056351808 cites W1971009901 @default.
• W2056351808 cites W1972994417 @default.
• W2056351808 cites W1980333967 @default.
• W2056351808 cites W1998093640 @default.
• W2056351808 cites W2001853114 @default.
• W2056351808 cites W2012080882 @default.
• W2056351808 cites W2017754929 @default.
• W2056351808 cites W2018885303 @default.
• W2056351808 cites W2020274584 @default.
• W2056351808 cites W2024338604 @default.
• W2056351808 cites W2031144266 @default.
• W2056351808 cites W2032233949 @default.
• W2056351808 cites W2033159509 @default.
• W2056351808 cites W2041720100 @default.
• W2056351808 cites W2042485714 @default.
• W2056351808 cites W2049442238 @default.
• W2056351808 cites W2057265189 @default.
• W2056351808 cites W2057424298 @default.
• W2056351808 cites W2059785438 @default.
• W2056351808 cites W2067883491 @default.
• W2056351808 cites W2079307058 @default.
• W2056351808 cites W2079319779 @default.
• W2056351808 cites W2088303320 @default.
• W2056351808 cites W2091060891 @default.
• W2056351808 cites W2091737589 @default.
• W2056351808 cites W2097292426 @default.
• W2056351808 cites W2106948759 @default.
• W2056351808 cites W2112897543 @default.
• W2056351808 cites W2113856487 @default.
• W2056351808 cites W2114725596 @default.
• W2056351808 cites W2118876391 @default.
• W2056351808 cites W2126618993 @default.
• W2056351808 cites W2127747996 @default.
• W2056351808 cites W2128931606 @default.
• W2056351808 cites W2138064823 @default.
• W2056351808 cites W2155205421 @default.
• W2056351808 cites W2156076504 @default.
• W2056351808 cites W2157169202 @default.
• W2056351808 cites W2166403013 @default.
• W2056351808 cites W2170194206 @default.
• W2056351808 cites W2327032162 @default.
• W2056351808 cites W2951178485 @default.
• W2056351808 cites W79013629 @default.
• W2056351808 doi "https://doi.org/10.1016/j.bcp.2007.07.011" @default.
• W2056351808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17707779" @default.
• W2056351808 hasPublicationYear "2007" @default.
• W2056351808 type Work @default.
• W2056351808 sameAs 2056351808 @default.
• W2056351808 citedByCount "225" @default.
• W2056351808 countsByYear W20563518082012 @default.
• W2056351808 countsByYear W20563518082013 @default.
• W2056351808 countsByYear W20563518082014 @default.
• W2056351808 countsByYear W20563518082015 @default.
• W2056351808 countsByYear W20563518082016 @default.
• W2056351808 countsByYear W20563518082017 @default.
• W2056351808 countsByYear W20563518082018 @default.
• W2056351808 countsByYear W20563518082019 @default.
• W2056351808 countsByYear W20563518082020 @default.
• W2056351808 countsByYear W20563518082021 @default.
• W2056351808 countsByYear W20563518082022 @default.
• W2056351808 countsByYear W20563518082023 @default.
• W2056351808 crossrefType "journal-article" @default.
• W2056351808 hasAuthorship W2056351808A5044940190 @default.
• W2056351808 hasAuthorship W2056351808A5063992837 @default.
• W2056351808 hasConcept C104292427 @default.
• W2056351808 hasConcept C104317684 @default.
• W2056351808 hasConcept C109964505 @default.
• W2056351808 hasConcept C116569031 @default.
• W2056351808 hasConcept C12554922 @default.
• W2056351808 hasConcept C151730666 @default.
• W2056351808 hasConcept C166342909 @default.
• W2056351808 hasConcept C170493617 @default.
• W2056351808 hasConcept C185592680 @default.
• W2056351808 hasConcept C188987157 @default.
• W2056351808 hasConcept C2776038425 @default.
• W2056351808 hasConcept C2776104367 @default.
• W2056351808 hasConcept C2779343474 @default.
• W2056351808 hasConcept C2779570518 @default.
• W2056351808 hasConcept C50254741 @default.
• W2056351808 hasConcept C55493867 @default.
• W2056351808 hasConcept C80161118 @default.
• W2056351808 hasConcept C82617044 @default.
• W2056351808 hasConcept C86803240 @default.

• next