FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056353674> ?p ?o ?g. }

• W2056353674 endingPage "e55757" @default.
• W2056353674 startingPage "e55757" @default.
• W2056353674 abstract "Ribs are primarily made of cortical bone and are necessary for chest expansion and ventilation. Rib fractures represent the most common type of non-traumatic fractures in the elderly yet few studies have focused on the biology of rib fragility. Here, we show that deletion of βcatenin in Col1a2 expressing osteoblasts of adult mice leads to aggressive osteoclastogenesis with increased serum levels of the osteoclastogenic cytokine RANKL, extensive rib resorption, multiple spontaneous rib fractures and chest wall deformities. Within days of osteoblast specific βcatenin deletion, animals die from respiratory failure with a vanishing rib cage that is unable to sustain ventilation. Increased bone resorption is also observed in the vertebrae and femur. Treatment with the bisphosphonate pamidronate delayed but did not prevent death or associated rib fractures. In contrast, administration of the glucocorticoid dexamethasone decreased serum RANKL and slowed osteoclastogenesis. Dexamethasone preserved rib structure, prevented respiratory compromise and strikingly increased survival. Our findings provide a novel model of accelerated osteoclastogenesis, where deletion of osteoblast βcatenin in adults leads to rapid development of destructive rib fractures. We demonstrate the role of βcatenin dependent mechanisms in rib fractures and suggest that glucocorticoids, by suppressing RANKL, may have a role in treating bone loss due to aggressive osteoclastogenesis." @default.
• W2056353674 created "2016-06-24" @default.
• W2056353674 creator A5008466775 @default.
• W2056353674 creator A5019894998 @default.
• W2056353674 creator A5028595728 @default.
• W2056353674 creator A5028997082 @default.
• W2056353674 creator A5037088741 @default.
• W2056353674 creator A5038285856 @default.
• W2056353674 creator A5042527382 @default.
• W2056353674 creator A5070581832 @default.
• W2056353674 creator A5071178498 @default.
• W2056353674 creator A5081441486 @default.
• W2056353674 creator A5091466574 @default.
• W2056353674 date "2013-02-05" @default.
• W2056353674 modified "2023-10-18" @default.
• W2056353674 title "Rib Fractures and Death from Deletion of Osteoblast βcatenin in Adult Mice Is Rescued by Corticosteroids" @default.
• W2056353674 cites W115384338 @default.
• W2056353674 cites W1966953695 @default.
• W2056353674 cites W1973142147 @default.
• W2056353674 cites W1981284961 @default.
• W2056353674 cites W1982395713 @default.
• W2056353674 cites W1989046476 @default.
• W2056353674 cites W1995358650 @default.
• W2056353674 cites W1999322873 @default.
• W2056353674 cites W2002095357 @default.
• W2056353674 cites W2004208129 @default.
• W2056353674 cites W2014362480 @default.
• W2056353674 cites W2015259527 @default.
• W2056353674 cites W2025542876 @default.
• W2056353674 cites W2030077822 @default.
• W2056353674 cites W2034541958 @default.
• W2056353674 cites W2035416199 @default.
• W2056353674 cites W2040870650 @default.
• W2056353674 cites W2041963088 @default.
• W2056353674 cites W2043129312 @default.
• W2056353674 cites W2066749771 @default.
• W2056353674 cites W2080089180 @default.
• W2056353674 cites W2086327907 @default.
• W2056353674 cites W2087665466 @default.
• W2056353674 cites W2093466133 @default.
• W2056353674 cites W2103445654 @default.
• W2056353674 cites W2103597610 @default.
• W2056353674 cites W2103737135 @default.
• W2056353674 cites W2122038117 @default.
• W2056353674 cites W2124495536 @default.
• W2056353674 cites W2147169743 @default.
• W2056353674 cites W2163341100 @default.
• W2056353674 cites W4236605623 @default.
• W2056353674 doi "https://doi.org/10.1371/journal.pone.0055757" @default.
• W2056353674 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3564851" @default.
• W2056353674 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23393600" @default.
• W2056353674 hasPublicationYear "2013" @default.
• W2056353674 type Work @default.
• W2056353674 sameAs 2056353674 @default.
• W2056353674 citedByCount "4" @default.
• W2056353674 countsByYear W20563536742013 @default.
• W2056353674 countsByYear W20563536742014 @default.
• W2056353674 countsByYear W20563536742015 @default.
• W2056353674 countsByYear W20563536742020 @default.
• W2056353674 crossrefType "journal-article" @default.
• W2056353674 hasAuthorship W2056353674A5008466775 @default.
• W2056353674 hasAuthorship W2056353674A5019894998 @default.
• W2056353674 hasAuthorship W2056353674A5028595728 @default.
• W2056353674 hasAuthorship W2056353674A5028997082 @default.
• W2056353674 hasAuthorship W2056353674A5037088741 @default.
• W2056353674 hasAuthorship W2056353674A5038285856 @default.
• W2056353674 hasAuthorship W2056353674A5042527382 @default.
• W2056353674 hasAuthorship W2056353674A5070581832 @default.
• W2056353674 hasAuthorship W2056353674A5071178498 @default.
• W2056353674 hasAuthorship W2056353674A5081441486 @default.
• W2056353674 hasAuthorship W2056353674A5091466574 @default.
• W2056353674 hasBestOaLocation W20563536741 @default.
• W2056353674 hasConcept C105702510 @default.
• W2056353674 hasConcept C126322002 @default.
• W2056353674 hasConcept C127413603 @default.
• W2056353674 hasConcept C134018914 @default.
• W2056353674 hasConcept C141071460 @default.
• W2056353674 hasConcept C146562846 @default.
• W2056353674 hasConcept C160306043 @default.
• W2056353674 hasConcept C170493617 @default.
• W2056353674 hasConcept C200457457 @default.
• W2056353674 hasConcept C202751555 @default.
• W2056353674 hasConcept C2776033226 @default.
• W2056353674 hasConcept C2776541429 @default.
• W2056353674 hasConcept C2778260815 @default.
• W2056353674 hasConcept C2779329777 @default.
• W2056353674 hasConcept C2779428903 @default.
• W2056353674 hasConcept C2780401358 @default.
• W2056353674 hasConcept C2781282405 @default.
• W2056353674 hasConcept C2911223091 @default.
• W2056353674 hasConcept C55493867 @default.
• W2056353674 hasConcept C673006 @default.
• W2056353674 hasConcept C71924100 @default.
• W2056353674 hasConcept C78519656 @default.
• W2056353674 hasConcept C86803240 @default.
• W2056353674 hasConcept C88045685 @default.
• W2056353674 hasConceptScore W2056353674C105702510 @default.
• W2056353674 hasConceptScore W2056353674C126322002 @default.

• next