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• W2056355344 startingPage "533" @default.
• W2056355344 abstract "Requirements for CD4+ T cell memory differentiation were analyzed with adoptively transferred SMARTA T cell receptor (TCR) transgenic cells specific for alymphocytic choriomeningitis virus (LCMV) epitope. LCMV-induced effector and memory differentiation of SMARTA cells mimicked the endogenous CD4+ T cell response. In contrast, infection with a recombinant Listeria expressing the LCMV epitope, although resulting initially in massive SMARTA expansion, led to loss of effector function and rapid cell death characterized by high expression of the apoptosis regulator Bim. Defective memory differentiation was seen after stimulation of naive but not memory SMARTA cells, was independent of precursor frequency, and correlated with a lower TCR avidity compared to endogenous responders. In addition, long-lived endogenous CD4+ memory T cells skewed to a higher functional avidity over time. These results support a model in which CD4+ T cell memory differentiation and longevity depend on the strength of the TCR signal during the primary response." @default.
• W2056355344 created "2016-06-24" @default.
• W2056355344 creator A5064599385 @default.
• W2056355344 creator A5085739337 @default.
• W2056355344 creator A5088675599 @default.
• W2056355344 date "2008-04-01" @default.
• W2056355344 modified "2023-10-18" @default.
• W2056355344 title "Rapid Culling of the CD4+ T Cell Repertoire in the Transition from Effector to Memory" @default.
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• W2056355344 doi "https://doi.org/10.1016/j.immuni.2008.02.014" @default.
• W2056355344 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2391296" @default.
• W2056355344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18356084" @default.
• W2056355344 hasPublicationYear "2008" @default.
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