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- W2056370411 abstract "RumA catalyzes transfer of a methyl group from S-adenosylmethionine (SAM) specifically to uridine 1939 of 23S ribosomal RNA in Escherichia coli to yield 5-methyluridine. We determined the crystal structure of RumA at 1.95 Å resolution. The protein is organized into three structural domains: The N-terminal domain contains sequence homology to the conserved TRAM motif and displays a five-stranded β barrel architecture characteristic of an oligosaccharide/oligonucleotide binding fold. The central domain contains a [Fe4S4] cluster coordinated by four conserved cysteine residues. The C-terminal domain displays the typical SAM-dependent methyltransferase fold. The catalytic nucleophile Cys389 lies in a motif different from that in DNA 5-methylcytosine methyltransferases. The electrostatic potential surface reveals a predominately positively charged area that covers the concave surface of the first two domains and suggests an RNA binding mode. The iron-sulfur cluster may be involved in the correct folding of the protein or may have a role in RNA binding." @default.
- W2056370411 created "2016-06-24" @default.
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- W2056370411 date "2004-03-01" @default.
- W2056370411 modified "2023-09-28" @default.
- W2056370411 title "Crystal Structure of RumA, an Iron-Sulfur Cluster Containing E. coli Ribosomal RNA 5-Methyluridine Methyltransferase" @default.
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- W2056370411 doi "https://doi.org/10.1016/j.str.2004.02.009" @default.
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