FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056371351> ?p ?o ?g. }

• W2056371351 endingPage "280" @default.
• W2056371351 startingPage "275" @default.
• W2056371351 abstract "Pharmacological properties of ionotropic glutamate receptors from Calliphora vicina larvae neuro-muscular junction (C. vicina iGlurs) were studied by two-electrode voltage-clamp technique. Characteristics of the ion channel pore were analyzed using a 26-member series of channel blockers, which includes mono- and dicationic derivatives of adamantane and phenylcyclohexyl. Structure-activity relationships were found to be markedly similar to the Ca2+-permeable AMPA receptors (AMPAR) but not NMDA receptors (NMDAR) channel subtype seen in vertebrates. Like AMPARs the channels of C. vicina iGlurs are sensitive mainly to dicationic compounds with 6-7 spacers between hydrophobic headgroup and terminal aminogroup. Study of the voltage dependence of block demonstrated that, like AMPARs, the C. vicina iGlur channels, are permeable to organic cations with dimensions exceeding 10 A. Concentration dependence of block suggests the presence of two distinct channel populations with approximately 20-fold different sensitivity to cationic blockers. The recognition domain properties are more complex. Besides glutamate, the channels can be activated by kainate, quisqualate and domoate. Competitive antagonists of AMPAR and NMDAR are virtually inactive against the C. vicina iGlurs as well as allosteric modulators GYKI 52466 and PEPA. Surprisingly, the responses were potentiated 3 times by 100 mkM of cyclothiazide. We conclude that the channel-forming domain of C. vicina iGlurs is AMPAR-like, whereas the recognition domain is specific." @default.
• W2056371351 created "2016-06-24" @default.
• W2056371351 creator A5007762732 @default.
• W2056371351 creator A5030029005 @default.
• W2056371351 creator A5046514504 @default.
• W2056371351 date "2009-04-01" @default.
• W2056371351 modified "2023-10-07" @default.
• W2056371351 title "Characterization of ionotropic glutamate receptors in insect neuro-muscular junction" @default.
• W2056371351 cites W1636225847 @default.
• W2056371351 cites W1658796519 @default.
• W2056371351 cites W1850125528 @default.
• W2056371351 cites W1916309944 @default.
• W2056371351 cites W1955231649 @default.
• W2056371351 cites W1978817835 @default.
• W2056371351 cites W1980486159 @default.
• W2056371351 cites W1980670924 @default.
• W2056371351 cites W1986923087 @default.
• W2056371351 cites W1989938166 @default.
• W2056371351 cites W1991437921 @default.
• W2056371351 cites W1997568797 @default.
• W2056371351 cites W1998347917 @default.
• W2056371351 cites W1998527404 @default.
• W2056371351 cites W1999347834 @default.
• W2056371351 cites W2002539991 @default.
• W2056371351 cites W2015409090 @default.
• W2056371351 cites W2015879192 @default.
• W2056371351 cites W2030131569 @default.
• W2056371351 cites W2035499517 @default.
• W2056371351 cites W2036080573 @default.
• W2056371351 cites W2037423018 @default.
• W2056371351 cites W2039350795 @default.
• W2056371351 cites W2043351688 @default.
• W2056371351 cites W2047180410 @default.
• W2056371351 cites W2054481542 @default.
• W2056371351 cites W2055320926 @default.
• W2056371351 cites W2057761743 @default.
• W2056371351 cites W2063987809 @default.
• W2056371351 cites W2070434577 @default.
• W2056371351 cites W2077052318 @default.
• W2056371351 cites W2079065235 @default.
• W2056371351 cites W2086974427 @default.
• W2056371351 cites W2089642515 @default.
• W2056371351 cites W2091837097 @default.
• W2056371351 cites W2093532462 @default.
• W2056371351 cites W2093910259 @default.
• W2056371351 cites W2095415935 @default.
• W2056371351 cites W2095714705 @default.
• W2056371351 cites W2132645376 @default.
• W2056371351 cites W2158822468 @default.
• W2056371351 cites W2168612663 @default.
• W2056371351 cites W2171021618 @default.
• W2056371351 cites W2409356041 @default.
• W2056371351 cites W49059005 @default.
• W2056371351 cites W49634699 @default.
• W2056371351 doi "https://doi.org/10.1016/j.cbpc.2008.07.010" @default.
• W2056371351 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18723120" @default.
• W2056371351 hasPublicationYear "2009" @default.
• W2056371351 type Work @default.
• W2056371351 sameAs 2056371351 @default.
• W2056371351 citedByCount "9" @default.
• W2056371351 countsByYear W20563713512012 @default.
• W2056371351 countsByYear W20563713512013 @default.
• W2056371351 countsByYear W20563713512019 @default.
• W2056371351 countsByYear W20563713512020 @default.
• W2056371351 countsByYear W20563713512021 @default.
• W2056371351 crossrefType "journal-article" @default.
• W2056371351 hasAuthorship W2056371351A5007762732 @default.
• W2056371351 hasAuthorship W2056371351A5030029005 @default.
• W2056371351 hasAuthorship W2056371351A5046514504 @default.
• W2056371351 hasConcept C115955781 @default.
• W2056371351 hasConcept C12554922 @default.
• W2056371351 hasConcept C136547172 @default.
• W2056371351 hasConcept C153461711 @default.
• W2056371351 hasConcept C160268369 @default.
• W2056371351 hasConcept C166342909 @default.
• W2056371351 hasConcept C170493617 @default.
• W2056371351 hasConcept C178790620 @default.
• W2056371351 hasConcept C185592680 @default.
• W2056371351 hasConcept C189184402 @default.
• W2056371351 hasConcept C2781001490 @default.
• W2056371351 hasConcept C50254741 @default.
• W2056371351 hasConcept C519063684 @default.
• W2056371351 hasConcept C55493867 @default.
• W2056371351 hasConcept C67018056 @default.
• W2056371351 hasConcept C71240020 @default.
• W2056371351 hasConcept C86803240 @default.
• W2056371351 hasConcept C88272193 @default.
• W2056371351 hasConceptScore W2056371351C115955781 @default.
• W2056371351 hasConceptScore W2056371351C12554922 @default.
• W2056371351 hasConceptScore W2056371351C136547172 @default.
• W2056371351 hasConceptScore W2056371351C153461711 @default.
• W2056371351 hasConceptScore W2056371351C160268369 @default.
• W2056371351 hasConceptScore W2056371351C166342909 @default.
• W2056371351 hasConceptScore W2056371351C170493617 @default.
• W2056371351 hasConceptScore W2056371351C178790620 @default.
• W2056371351 hasConceptScore W2056371351C185592680 @default.
• W2056371351 hasConceptScore W2056371351C189184402 @default.
• W2056371351 hasConceptScore W2056371351C2781001490 @default.

• next