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- W2056389623 abstract "There are 2 main groups of breast cysts characterized by their intracystic sodium-to-potassium ratios. Women who have intracystic Na/K < 3 may have a higher risk of developing breast cancer than those who have intracystic Na/K > 3. The cell adhesion molecule, ICAM-1, has been shown to be inducible by interleukin-1 (IL-1). Furthermore, ICAM-1 may be involved in the progression of metastasis in certain malignancies. The aim of this study was to measure intracystic soluble ICAM-1 (sICAMu-l) and IL-1 α/β levels and to assess the relationships between these substances. Wide-ranging concentrations of sICAM-1, IL-1α and IL-1β were found in breast-cyst fluid. The high-electrolyte-ratio group had intracystic levels of sICAM-1 and IL-1β which were significantly higher than those of the low-electrolyte-ratio group. No significant difference was found between IL-1α concentrations in the 2 groups of breast cysts. Strong positive correlations were found between sICAM-1 and IL-1α, sICAM-1 and IL-1β, and IL-1α and IL-1β. The significance of the higher concentrations of sICAM-1 in the high-electrolyte-ratio group remains to be determined, but the results of this study suggest that sICAM-1 levels in the high-electrolyte-ratio group may be regulated in part by IL-1α and IL-1β." @default.
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- W2056389623 date "1993-10-21" @default.
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- W2056389623 title "Possible regulation of soluble icam-1 levels by interleukin-1 in a sub-set of breast cysts" @default.
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- W2056389623 doi "https://doi.org/10.1002/ijc.2910550412" @default.
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