FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056420006> ?p ?o ?g. }

• W2056420006 endingPage "e2004" @default.
• W2056420006 startingPage "e2004" @default.
• W2056420006 abstract "Background Chikungunya virus (CHIKV) is responsible for acute febrile polyarthralgia and, in a proportion of cases, severe complications including chronic arthritis. CHIKV has spread recently in East Africa, South-West Indian Ocean, South-Asia and autochthonous cases have been reported in Europe. Although almost all patients are outpatients, medical investigations mainly focused on hospitalised patients. Methodology/Principal Findings Here, we detail clinico-biological characteristics of Chikungunya (CHIK) outpatients in Reunion Island (2006). 76 outpatients with febrile arthralgia diagnosed within less than 48 hours were included by general practitioners during the CuraChik clinical trial. CHIK was confirmed in 54 patients and excluded in 22. A detailed clinical and biological follow-up was organised, that included analysis of viral intrahost diversity and telephone survey until day 300. The evolution of acute CHIK included 2 stages: the ‘viral stage’ (day 1–day 4) was associated with rapid decrease of viraemia and improvement of clinical presentation; the ‘convalescent stage’ (day 5–day 14) was associated with no detectable viraemia but a slower clinical improvement. Women and elderly had a significantly higher number of arthralgia at inclusion and at day 300. Based on the study clinico-biological dataset, scores for CHIK diagnosis in patients with recent febrile acute polyarthralgia were elaborated using arthralgia on hands and wrists, a minor or absent myalgia and the presence of lymphopenia (<1G/L) as major orientation criteria. Finally, we observed that CHIKV intra-host genetic diversity increased over time and that a higher viral amino-acid complexity at the acute stage was associated with increased number of arthralgia and intensity of sequelae at day 300. Conclusions/Significance This study provided a detailed picture of clinico-biological CHIK evolution at the acute phase of the disease, allowed the elaboration of scores to assist CHIK diagnosis and investigated for the first time the impact of viral intra-host genetic diversity on the disease course." @default.
• W2056420006 created "2016-06-24" @default.
• W2056420006 creator A5022407583 @default.
• W2056420006 creator A5043268412 @default.
• W2056420006 creator A5067395185 @default.
• W2056420006 creator A5068360960 @default.
• W2056420006 creator A5077748740 @default.
• W2056420006 creator A5077750825 @default.
• W2056420006 date "2013-01-17" @default.
• W2056420006 modified "2023-10-03" @default.
• W2056420006 title "Chikungunya Fever: A Clinical and Virological Investigation of Outpatients on Reunion Island, South-West Indian Ocean" @default.
• W2056420006 cites W1966353112 @default.
• W2056420006 cites W1966769229 @default.
• W2056420006 cites W1971707621 @default.
• W2056420006 cites W1974280310 @default.
• W2056420006 cites W1976841934 @default.
• W2056420006 cites W1989223711 @default.
• W2056420006 cites W2001316624 @default.
• W2056420006 cites W2008706269 @default.
• W2056420006 cites W2009111710 @default.
• W2056420006 cites W2014884239 @default.
• W2056420006 cites W2016270731 @default.
• W2056420006 cites W2021307858 @default.
• W2056420006 cites W2026949398 @default.
• W2056420006 cites W2035587893 @default.
• W2056420006 cites W2039964691 @default.
• W2056420006 cites W2040753525 @default.
• W2056420006 cites W2052129607 @default.
• W2056420006 cites W2062504884 @default.
• W2056420006 cites W2068012691 @default.
• W2056420006 cites W2070952377 @default.
• W2056420006 cites W2071258824 @default.
• W2056420006 cites W2087854601 @default.
• W2056420006 cites W2093309856 @default.
• W2056420006 cites W2100048187 @default.
• W2056420006 cites W2100160661 @default.
• W2056420006 cites W2100320240 @default.
• W2056420006 cites W2102392703 @default.
• W2056420006 cites W2105252537 @default.
• W2056420006 cites W2106309247 @default.
• W2056420006 cites W2110464701 @default.
• W2056420006 cites W2112497696 @default.
• W2056420006 cites W2120801593 @default.
• W2056420006 cites W2125121305 @default.
• W2056420006 cites W2127427126 @default.
• W2056420006 cites W2133780470 @default.
• W2056420006 cites W2136631930 @default.
• W2056420006 cites W2138567044 @default.
• W2056420006 cites W2141987735 @default.
• W2056420006 cites W2143811778 @default.
• W2056420006 cites W2150648604 @default.
• W2056420006 cites W2168518217 @default.
• W2056420006 cites W2170388413 @default.
• W2056420006 cites W2396632389 @default.
• W2056420006 cites W4292543873 @default.
• W2056420006 doi "https://doi.org/10.1371/journal.pntd.0002004" @default.
• W2056420006 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3547841" @default.
• W2056420006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23350006" @default.
• W2056420006 hasPublicationYear "2013" @default.
• W2056420006 type Work @default.
• W2056420006 sameAs 2056420006 @default.
• W2056420006 citedByCount "140" @default.
• W2056420006 countsByYear W20564200062013 @default.
• W2056420006 countsByYear W20564200062014 @default.
• W2056420006 countsByYear W20564200062015 @default.
• W2056420006 countsByYear W20564200062016 @default.
• W2056420006 countsByYear W20564200062017 @default.
• W2056420006 countsByYear W20564200062018 @default.
• W2056420006 countsByYear W20564200062019 @default.
• W2056420006 countsByYear W20564200062020 @default.
• W2056420006 countsByYear W20564200062021 @default.
• W2056420006 countsByYear W20564200062022 @default.
• W2056420006 countsByYear W20564200062023 @default.
• W2056420006 crossrefType "journal-article" @default.
• W2056420006 hasAuthorship W2056420006A5022407583 @default.
• W2056420006 hasAuthorship W2056420006A5043268412 @default.
• W2056420006 hasAuthorship W2056420006A5067395185 @default.
• W2056420006 hasAuthorship W2056420006A5068360960 @default.
• W2056420006 hasAuthorship W2056420006A5077748740 @default.
• W2056420006 hasAuthorship W2056420006A5077750825 @default.
• W2056420006 hasBestOaLocation W20564200061 @default.
• W2056420006 hasConcept C126322002 @default.
• W2056420006 hasConcept C159047783 @default.
• W2056420006 hasConcept C187212893 @default.
• W2056420006 hasConcept C2778616394 @default.
• W2056420006 hasConcept C2781273456 @default.
• W2056420006 hasConcept C533803919 @default.
• W2056420006 hasConcept C71924100 @default.
• W2056420006 hasConceptScore W2056420006C126322002 @default.
• W2056420006 hasConceptScore W2056420006C159047783 @default.
• W2056420006 hasConceptScore W2056420006C187212893 @default.
• W2056420006 hasConceptScore W2056420006C2778616394 @default.
• W2056420006 hasConceptScore W2056420006C2781273456 @default.
• W2056420006 hasConceptScore W2056420006C533803919 @default.
• W2056420006 hasConceptScore W2056420006C71924100 @default.
• W2056420006 hasIssue "1" @default.
• W2056420006 hasLocation W20564200061 @default.
• W2056420006 hasLocation W20564200062 @default.

• next