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• W2056420199 abstract "ObjectiveTo determine the accuracy of outpatient miniature hysteroscopy in the diagnosis of premalignant and malignant endometrial lesions.DesignA prospective cohort study (1996–1997).SettingMinimal access surgical training centre in a large teaching hospital.MethodsOutpatient hysteroscopy and endometrial sampling was carried out on 248 patients with abnormal uterine bleeding. Any patients unable to undergo these outpatient procedures were admitted for a formal inpatient hysteroscopy and curettage. Test performance characteristics were computed for hysteroscopy, comparing its findings with the histological diagnosis which served as a ‘gold standard’.Main outcome measuresThe estimate of the accuracy of the hysteroscopic findings was based, for binary results, on sensitivity, specificity and predictive values. For multilevel results, the diagnostic accuracy was computed using likelihood ratios (LRs). With a normal hysteroscopy result, an LR of 1 indicated an increased probability that such a lesion was present.ResultsHysteroscopy revealed features of normal endometrium in 228 women, of whom 12 were found histologically to have premalignant hyperplasia/cancer. Hysteroscopic features of premalignant/malignant endometrial lesions were suspected in 20 patients but the diagnosis was confirmed histologically in six cases only. This amounted to a sensitivity of 33.3% (95% confidence intervals (CI) 14.4–58.8), a specificity of 93.9% (95% CI 89.8–96.5), a positive predictive value of 30.3%. (95% CI 12.8–54.3), and a negative predictive value of 94.7%. (95%CI 90.8–97.1). Analysis using likelihood ratios revealed that for a normal hysteroscopy the LR was 0.7 (95% CI 0.5–0.9). The LR was 1.9 (95% CI 0.5–6.6) when there was intermediate abnormality (increased endometrial thickness, abnormal vascularization, polypoid formations, mamillations and cerebroid irregularities). The LR was 51.1 (95% CI 7.9–326.9) when there was definite hysteroscopic abnormality (intermediate abnormality features associated with irregular polylobular friable excrescences with necrosis or bleeding).ConclusionThe probability of the presence of a premalignant/malignant lesion is not particularly altered by the finding of normal hysteroscopic appearances or of intermediately abnormal features. However, if the hysteroscopic findings are definitely abnormal, the probability of there being a premalignant/malignant lesion is substantially increased. Normal findings at hysteroscopy are not conclusive and do not eliminate the need for endometrial sampling as they are not a substitute for benign findings on histological investigation." @default.
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• W2056420199 date "1999-06-01" @default.
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• W2056420199 title "The diagnostic accuracy of outpatient miniature hysteroscopy in predicting premalignant and malignant endometrial lesions" @default.
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• W2056420199 doi "https://doi.org/10.1046/j.1365-2508.1999.00255.x" @default.
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