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• W2056442009 abstract "Significance Twister is a small self-cleaving ribozyme similar in size to the hammerhead ribozyme but uses an orthogonal fold for a similar catalytic rate constant. However, the mechanistic source of the catalytic rate increase generated by twister was unknown. We present crystal structures of twister from Orzyza sativa as well as a twister sequence from an organism that has not been cultured in isolation and identify RNA nucleotides that are vital for self-cleavage, suggest their catalytic roles, and update twister’s conserved secondary structure model." @default.
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• W2056442009 date "2014-08-25" @default.
• W2056442009 modified "2023-10-17" @default.
• W2056442009 title "Structural basis for the fast self-cleavage reaction catalyzed by the twister ribozyme" @default.
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• W2056442009 doi "https://doi.org/10.1073/pnas.1414571111" @default.
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