Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056451421> ?p ?o ?g. }
- W2056451421 endingPage "313" @default.
- W2056451421 startingPage "300" @default.
- W2056451421 abstract "Gefitinib and erlotinib are the two anti-epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) approved for treatment of advanced NSCLC patients. These drugs target one of the most important pathways in lung carcinogenesis and are able to exploit the phenomenon of ‘oncogene addiction’, with different efficacy according to EGFR gene mutational status in tumor samples. Gefitinib has been approved only for EGFR mutation bearing patients regardless the line of treatment, while erlotinib is also indicated in patients without EGFR mutation who undergo second- or third-line treatment. Some studies evaluated the main differences between these drugs both for direct comparison and to improve their sequential use. In particular, toxicity profile resulted partially different, and these observations may be explained by several molecular and pharmacokinetic features. Therefore, this review integrates preclinical data with clinical evidences of TKIs to guide the optimization of currently available treatments in advanced NSCLC patients." @default.
- W2056451421 created "2016-06-24" @default.
- W2056451421 creator A5000995161 @default.
- W2056451421 creator A5004175335 @default.
- W2056451421 creator A5006712720 @default.
- W2056451421 creator A5026050980 @default.
- W2056451421 creator A5034546500 @default.
- W2056451421 creator A5041229832 @default.
- W2056451421 creator A5055153013 @default.
- W2056451421 creator A5055919267 @default.
- W2056451421 creator A5056727791 @default.
- W2056451421 creator A5074506844 @default.
- W2056451421 creator A5075882076 @default.
- W2056451421 creator A5085722313 @default.
- W2056451421 date "2014-02-01" @default.
- W2056451421 modified "2023-09-25" @default.
- W2056451421 title "Are erlotinib and gefitinib interchangeable, opposite or complementary for non-small cell lung cancer treatment? Biological, pharmacological and clinical aspects" @default.
- W2056451421 cites W1964321121 @default.
- W2056451421 cites W1965129132 @default.
- W2056451421 cites W1969116196 @default.
- W2056451421 cites W1985398792 @default.
- W2056451421 cites W1988257756 @default.
- W2056451421 cites W1989510858 @default.
- W2056451421 cites W1993474259 @default.
- W2056451421 cites W1993718411 @default.
- W2056451421 cites W1994567819 @default.
- W2056451421 cites W1997134098 @default.
- W2056451421 cites W1997678366 @default.
- W2056451421 cites W1998499306 @default.
- W2056451421 cites W2005364602 @default.
- W2056451421 cites W2006262863 @default.
- W2056451421 cites W2008779407 @default.
- W2056451421 cites W2011450183 @default.
- W2056451421 cites W2014390227 @default.
- W2056451421 cites W2015239877 @default.
- W2056451421 cites W2019236425 @default.
- W2056451421 cites W2029633750 @default.
- W2056451421 cites W2032989970 @default.
- W2056451421 cites W2037791152 @default.
- W2056451421 cites W2040181388 @default.
- W2056451421 cites W2043696829 @default.
- W2056451421 cites W2045124668 @default.
- W2056451421 cites W2045626426 @default.
- W2056451421 cites W2047665602 @default.
- W2056451421 cites W2056743298 @default.
- W2056451421 cites W2070232725 @default.
- W2056451421 cites W2070444157 @default.
- W2056451421 cites W2072978123 @default.
- W2056451421 cites W2078943728 @default.
- W2056451421 cites W2081534823 @default.
- W2056451421 cites W2086936470 @default.
- W2056451421 cites W2090200456 @default.
- W2056451421 cites W2092652029 @default.
- W2056451421 cites W2096786080 @default.
- W2056451421 cites W2100912832 @default.
- W2056451421 cites W2101035251 @default.
- W2056451421 cites W2102088611 @default.
- W2056451421 cites W2104251051 @default.
- W2056451421 cites W2104748005 @default.
- W2056451421 cites W2105341103 @default.
- W2056451421 cites W2106037631 @default.
- W2056451421 cites W2107304950 @default.
- W2056451421 cites W2107487953 @default.
- W2056451421 cites W2110835998 @default.
- W2056451421 cites W2111109297 @default.
- W2056451421 cites W2111662961 @default.
- W2056451421 cites W2111973486 @default.
- W2056451421 cites W2113491100 @default.
- W2056451421 cites W2118548009 @default.
- W2056451421 cites W2120718661 @default.
- W2056451421 cites W2122553809 @default.
- W2056451421 cites W2123776480 @default.
- W2056451421 cites W2125129553 @default.
- W2056451421 cites W2127101185 @default.
- W2056451421 cites W2129360604 @default.
- W2056451421 cites W2129787264 @default.
- W2056451421 cites W2132157071 @default.
- W2056451421 cites W2135192471 @default.
- W2056451421 cites W2138297714 @default.
- W2056451421 cites W2138404775 @default.
- W2056451421 cites W2139236349 @default.
- W2056451421 cites W2139702493 @default.
- W2056451421 cites W2146404049 @default.
- W2056451421 cites W2151239501 @default.
- W2056451421 cites W2151536438 @default.
- W2056451421 cites W2152241526 @default.
- W2056451421 cites W2152755651 @default.
- W2056451421 cites W2153477391 @default.
- W2056451421 cites W2153942353 @default.
- W2056451421 cites W2154226624 @default.
- W2056451421 cites W2154662831 @default.
- W2056451421 cites W2157077639 @default.
- W2056451421 cites W2159013299 @default.
- W2056451421 cites W2159023488 @default.
- W2056451421 cites W2160300997 @default.
- W2056451421 cites W2160901388 @default.
- W2056451421 cites W2160982674 @default.
- W2056451421 cites W2161821474 @default.