Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056455839> ?p ?o ?g. }
- W2056455839 endingPage "3527" @default.
- W2056455839 startingPage "3509" @default.
- W2056455839 abstract "Selenium (Se) deficiency has been known for many years to be associated with disease, impaired growth and a variety of other metabolic disorders in mammals. Only recently has the major role that Se-containing proteins, designated selenoproteins, play in many aspects of health and development begun to emerge. Se is incorporated into protein by way of the Se-containing amino acid, selenocysteine (Sec). The synthesis of selenoproteins is dependent on Sec tRNA for insertion of Sec, the 21st amino acid in the genetic code, into protein. We have taken advantage of this dependency to modulate the expression of Sec tRNA that in turn modulates the expression of selenoproteins by generating transgenic, conditional knockout, transgenic/standard knockout and transgenic/conditional knockout mouse models, all of which involve the Sec tRNA gene, to elucidate the intracellular roles of this protein class." @default.
- W2056455839 created "2016-06-24" @default.
- W2056455839 creator A5010080171 @default.
- W2056455839 creator A5013175503 @default.
- W2056455839 creator A5035878254 @default.
- W2056455839 creator A5048138321 @default.
- W2056455839 creator A5069088895 @default.
- W2056455839 date "2009-09-10" @default.
- W2056455839 modified "2023-09-26" @default.
- W2056455839 title "Mouse Models Targeting Selenocysteine tRNA Expression for Elucidating the Role of Selenoproteins in Health and Development" @default.
- W2056455839 cites W1501074197 @default.
- W2056455839 cites W1502260395 @default.
- W2056455839 cites W1604177250 @default.
- W2056455839 cites W1890664047 @default.
- W2056455839 cites W191709639 @default.
- W2056455839 cites W1924557165 @default.
- W2056455839 cites W1926614894 @default.
- W2056455839 cites W1953661334 @default.
- W2056455839 cites W1960984556 @default.
- W2056455839 cites W1965192528 @default.
- W2056455839 cites W1967422373 @default.
- W2056455839 cites W1967785063 @default.
- W2056455839 cites W1976852255 @default.
- W2056455839 cites W1982954865 @default.
- W2056455839 cites W1989926731 @default.
- W2056455839 cites W1990660710 @default.
- W2056455839 cites W1999371773 @default.
- W2056455839 cites W2006313098 @default.
- W2056455839 cites W2008097674 @default.
- W2056455839 cites W2009396441 @default.
- W2056455839 cites W2011427262 @default.
- W2056455839 cites W2025914723 @default.
- W2056455839 cites W2030654895 @default.
- W2056455839 cites W2039994945 @default.
- W2056455839 cites W2041941808 @default.
- W2056455839 cites W2043443567 @default.
- W2056455839 cites W2043675751 @default.
- W2056455839 cites W2045204680 @default.
- W2056455839 cites W2050671563 @default.
- W2056455839 cites W2051088385 @default.
- W2056455839 cites W2053220031 @default.
- W2056455839 cites W2054780866 @default.
- W2056455839 cites W2056584403 @default.
- W2056455839 cites W2060555072 @default.
- W2056455839 cites W2060721215 @default.
- W2056455839 cites W2065203267 @default.
- W2056455839 cites W2073485361 @default.
- W2056455839 cites W2075786756 @default.
- W2056455839 cites W2087724791 @default.
- W2056455839 cites W2088145955 @default.
- W2056455839 cites W2090400746 @default.
- W2056455839 cites W2098890352 @default.
- W2056455839 cites W2099286609 @default.
- W2056455839 cites W2101123075 @default.
- W2056455839 cites W2102500963 @default.
- W2056455839 cites W2103987923 @default.
- W2056455839 cites W2105299400 @default.
- W2056455839 cites W2107129827 @default.
- W2056455839 cites W2107521540 @default.
- W2056455839 cites W2108136855 @default.
- W2056455839 cites W2109458276 @default.
- W2056455839 cites W2109969762 @default.
- W2056455839 cites W2112955839 @default.
- W2056455839 cites W2115560639 @default.
- W2056455839 cites W2120722077 @default.
- W2056455839 cites W2122210015 @default.
- W2056455839 cites W2123686364 @default.
- W2056455839 cites W2130693604 @default.
- W2056455839 cites W2135905023 @default.
- W2056455839 cites W2136371225 @default.
- W2056455839 cites W2141386840 @default.
- W2056455839 cites W2141801332 @default.
- W2056455839 cites W2142718693 @default.
- W2056455839 cites W2143629835 @default.
- W2056455839 cites W2158106682 @default.
- W2056455839 cites W2159797128 @default.
- W2056455839 cites W2160076700 @default.
- W2056455839 cites W2161327412 @default.
- W2056455839 cites W2165072468 @default.
- W2056455839 cites W2168115581 @default.
- W2056455839 cites W2168163140 @default.
- W2056455839 cites W2168433858 @default.
- W2056455839 cites W2172183886 @default.
- W2056455839 cites W2210241620 @default.
- W2056455839 cites W2323932332 @default.
- W2056455839 cites W2395712602 @default.
- W2056455839 cites W2401106597 @default.
- W2056455839 cites W2505529799 @default.
- W2056455839 doi "https://doi.org/10.3390/molecules14093509" @default.
- W2056455839 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3459062" @default.
- W2056455839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19783940" @default.
- W2056455839 hasPublicationYear "2009" @default.
- W2056455839 type Work @default.
- W2056455839 sameAs 2056455839 @default.
- W2056455839 citedByCount "43" @default.
- W2056455839 countsByYear W20564558392012 @default.
- W2056455839 countsByYear W20564558392013 @default.
- W2056455839 countsByYear W20564558392014 @default.