Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056460716> ?p ?o ?g. }
- W2056460716 endingPage "594" @default.
- W2056460716 startingPage "585" @default.
- W2056460716 abstract "Studies of the prognostic value of Ishak fibrosis stage are lacking. We used multi-year follow-up of the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial to determine whether individual Ishak fibrosis stages predicted clinical outcomes in patients with chronic hepatitis C. Baseline liver biopsy specimens from 1050 patients with compensated chronic hepatitis C who had failed combination peginterferon and ribavirin were reviewed by a panel of expert hepatopathologists. Fibrosis was staged with the Ishak scale (ranging from 0 = no fibrosis to 6 = cirrhosis). Biopsy fragmentation and length as well as number of portal tracts were recorded. We compared rates of prespecified clinical outcomes of hepatic decompensation and hepatocellular carcinoma across individual Ishak fibrosis stages. Of 1050 biopsy specimens, 25% were fragmented, 63% longer than 1.5 cm, 69% larger than 10 mm2, and 75% had 10 or more portal tracts. Baseline laboratory markers of liver disease severity were worse and the frequency of esophageal varices higher with increasing Ishak stage (P < 0.0001). The 6-year cumulative incidence of first clinical outcome was 5.6% for stage 2, 16.1% for stage 3, 19.3% for stage 4, 37.8% for stage 5, and 49.3% for stage 6. Among nonfragmented biopsy specimens, the predictive ability of Ishak staging was enhanced; however, no association was observed between Ishak stage and outcomes for fragmented biopsy specimens because of high rates of outcomes for patients with noncirrhotic stages. Similar results were observed with liver transplantation or liver-related death as the outcome. Conclusion: Ishak fibrosis stage predicts clinical outcomes, need for liver transplantation, and liver-related death in patients with chronic hepatitis C. Patients with fragmented biopsy specimens with low Ishak stage may be understaged histologically. (HEPATOLOGY 2010;51:585–594.)" @default.
- W2056460716 created "2016-06-24" @default.
- W2056460716 creator A5005769736 @default.
- W2056460716 creator A5013138122 @default.
- W2056460716 creator A5018051199 @default.
- W2056460716 creator A5024470010 @default.
- W2056460716 creator A5034688760 @default.
- W2056460716 creator A5043162110 @default.
- W2056460716 creator A5051411123 @default.
- W2056460716 creator A5060686427 @default.
- W2056460716 creator A5064025296 @default.
- W2056460716 creator A5065989965 @default.
- W2056460716 creator A5066255279 @default.
- W2056460716 creator A5069338422 @default.
- W2056460716 creator A5072014736 @default.
- W2056460716 creator A5083962400 @default.
- W2056460716 creator A5085891308 @default.
- W2056460716 creator A5086380045 @default.
- W2056460716 date "2009-09-14" @default.
- W2056460716 modified "2023-10-03" @default.
- W2056460716 title "Prognostic value of Ishak fibrosis stage: Findings from the hepatitis C antiviral long-term treatment against cirrhosis trial" @default.
- W2056460716 cites W1577206569 @default.
- W2056460716 cites W1964051982 @default.
- W2056460716 cites W1966492770 @default.
- W2056460716 cites W1967851907 @default.
- W2056460716 cites W1981900811 @default.
- W2056460716 cites W1983086656 @default.
- W2056460716 cites W1995813950 @default.
- W2056460716 cites W2016409892 @default.
- W2056460716 cites W2021150659 @default.
- W2056460716 cites W2033348731 @default.
- W2056460716 cites W2054087587 @default.
- W2056460716 cites W2061175282 @default.
- W2056460716 cites W2090439540 @default.
- W2056460716 cites W2091651967 @default.
- W2056460716 cites W2094087831 @default.
- W2056460716 cites W2094174828 @default.
- W2056460716 cites W2115956200 @default.
- W2056460716 cites W2129712640 @default.
- W2056460716 cites W2155510029 @default.
- W2056460716 cites W2160029914 @default.
- W2056460716 cites W2162389892 @default.
- W2056460716 cites W4211191129 @default.
- W2056460716 cites W78626345 @default.
- W2056460716 doi "https://doi.org/10.1002/hep.23315" @default.
- W2056460716 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3814134" @default.
- W2056460716 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20101752" @default.
- W2056460716 hasPublicationYear "2009" @default.
- W2056460716 type Work @default.
- W2056460716 sameAs 2056460716 @default.
- W2056460716 citedByCount "148" @default.
- W2056460716 countsByYear W20564607162012 @default.
- W2056460716 countsByYear W20564607162013 @default.
- W2056460716 countsByYear W20564607162014 @default.
- W2056460716 countsByYear W20564607162015 @default.
- W2056460716 countsByYear W20564607162016 @default.
- W2056460716 countsByYear W20564607162017 @default.
- W2056460716 countsByYear W20564607162018 @default.
- W2056460716 countsByYear W20564607162019 @default.
- W2056460716 countsByYear W20564607162020 @default.
- W2056460716 countsByYear W20564607162021 @default.
- W2056460716 countsByYear W20564607162022 @default.
- W2056460716 countsByYear W20564607162023 @default.
- W2056460716 crossrefType "journal-article" @default.
- W2056460716 hasAuthorship W2056460716A5005769736 @default.
- W2056460716 hasAuthorship W2056460716A5013138122 @default.
- W2056460716 hasAuthorship W2056460716A5018051199 @default.
- W2056460716 hasAuthorship W2056460716A5024470010 @default.
- W2056460716 hasAuthorship W2056460716A5034688760 @default.
- W2056460716 hasAuthorship W2056460716A5043162110 @default.
- W2056460716 hasAuthorship W2056460716A5051411123 @default.
- W2056460716 hasAuthorship W2056460716A5060686427 @default.
- W2056460716 hasAuthorship W2056460716A5064025296 @default.
- W2056460716 hasAuthorship W2056460716A5065989965 @default.
- W2056460716 hasAuthorship W2056460716A5066255279 @default.
- W2056460716 hasAuthorship W2056460716A5069338422 @default.
- W2056460716 hasAuthorship W2056460716A5072014736 @default.
- W2056460716 hasAuthorship W2056460716A5083962400 @default.
- W2056460716 hasAuthorship W2056460716A5085891308 @default.
- W2056460716 hasAuthorship W2056460716A5086380045 @default.
- W2056460716 hasBestOaLocation W20564607161 @default.
- W2056460716 hasConcept C126322002 @default.
- W2056460716 hasConcept C146357865 @default.
- W2056460716 hasConcept C151730666 @default.
- W2056460716 hasConcept C2775934546 @default.
- W2056460716 hasConcept C2776455275 @default.
- W2056460716 hasConcept C2777214474 @default.
- W2056460716 hasConcept C2777766500 @default.
- W2056460716 hasConcept C2778019345 @default.
- W2056460716 hasConcept C2779609443 @default.
- W2056460716 hasConcept C2780559512 @default.
- W2056460716 hasConcept C2911091166 @default.
- W2056460716 hasConcept C41260117 @default.
- W2056460716 hasConcept C71924100 @default.
- W2056460716 hasConcept C86803240 @default.
- W2056460716 hasConcept C90924648 @default.
- W2056460716 hasConceptScore W2056460716C126322002 @default.
- W2056460716 hasConceptScore W2056460716C146357865 @default.