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• W2056464180 abstract "You have accessJournal of UrologyBladder Cancer: Natural History and Pathophysiology1 Apr 2015MP64-19 THE NATURAL HISTORY OF NON-MUSCLE INVASIVE, NESTED VARIANT OF UROTHELIAL CARCINOMA Abhijith Mally, Amy Tin, Eugene Cha, Sherri Donat, Harry Herr, Bernard Bochner, Daniel Sjoberg, and Guido Dalbagni Abhijith MallyAbhijith Mally More articles by this author , Amy TinAmy Tin More articles by this author , Eugene ChaEugene Cha More articles by this author , Sherri DonatSherri Donat More articles by this author , Harry HerrHarry Herr More articles by this author , Bernard BochnerBernard Bochner More articles by this author , Daniel SjobergDaniel Sjoberg More articles by this author , and Guido DalbagniGuido Dalbagni More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.2330AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES We evaluated patients followed with non-muscle invasive, nested variant of urothelial carcinoma and compared progression and survival outcomes to patients with pure urothelial carcinoma. METHODS We identified 4086 patients with bladder cancer who presented with pTa, pTis, or pT1 at diagnosis. Among this cohort, there were 3897 patients with pure urothelial carcinoma and 92 patients were found to have nested variant features at some point during followup. In order to assess whether there is a difference in progression-free survival (PFS) between NMIBC patients with pure urothelial carcinoma and those with nested features, we utilized multivariable Cox proportional hazards models adjusting for gender, age and tumor stage (pT1 vs pTa/pTis) at diagnosis. A univariate Cox proportional hazards model was used to assess difference in overall survival (OS) based on nested or pure urothelial carcinoma histology. RESULTS On univariate analysis, nested variant was found to be significantly associated with poorer PFS (HR 6.25; 95% C.I. 4.52, 8.65; p < 0.0001). Hazard ratios were similar after adjusting for standard predictors on multivariable analysis, (HR: 4.12; 95% C.I. 2.98, 5.69; p < 0.0001). Figure 1 displays the PFS curves for UC vs. nested-features estimated from our multivariable Cox proportional hazard models based on the covariate values of the average patient with nested features: 65 year old, male patient with a diagnostic tumor stage of pT1. On univariate analysis, having nested variant was found to be significantly associated with poorer OS (HR 1.97; 95% C.I. 1.45, 2.67; p < 0.0001). CONCLUSIONS Non-muscle invasive, nested variant of urothelial carcinoma is associated with significantly poorer PFS and OS compared with pure urothelial carcinoma, suggesting that these patients should be considered for more aggressive surveillance and earlier treatment. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e806 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Abhijith Mally More articles by this author Amy Tin More articles by this author Eugene Cha More articles by this author Sherri Donat More articles by this author Harry Herr More articles by this author Bernard Bochner More articles by this author Daniel Sjoberg More articles by this author Guido Dalbagni More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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• W2056464180 date "2015-04-01" @default.
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• W2056464180 title "MP64-19 THE NATURAL HISTORY OF NON-MUSCLE INVASIVE, NESTED VARIANT OF UROTHELIAL CARCINOMA" @default.
• W2056464180 doi "https://doi.org/10.1016/j.juro.2015.02.2330" @default.
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