FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056475263> ?p ?o ?g. }

• W2056475263 endingPage "515" @default.
• W2056475263 startingPage "505" @default.
• W2056475263 abstract "Chromosomal instability (CIN) is a common feature of malignant tumors. Centrosome hyperamplification (CH) occurs frequently in human cancers, and may be a contributing factor in CIN. In this study, we investigated the relationship between CH and CIN in bladder cancer.Clinical samples obtained by transurethral resection from 22 patients with bladder cancer were examined (histological grade G1, 5 cases; G2, 6 cases; G3, 11 cases). CH was evaluated by immunohistochemistry using anti-pericentrin antibody. CIN was evaluated by fluorescence in situ hybridization (FISH). FISH probes for pericentromeric regions of chromosomes 3, 7, and 17 were hybridized to touch preparations of nuclei from frozen tissues. We also analyzed the centrosome replication cycle of bladder cancer by laser scanning cytometry (LSC).Of the 22 cases examined, 18 (81.8%) had centrosome hyperamplification: CH 0, 4 cases (18.1%); CH I, 5 cases (22.7%); CH II, 5 cases (22.7%); CH III, 8 cases (36.4%). The grade of CH was directly proportional to the histological grade (p=0.03, chi(2) test). LSC analysis showed that the centrosome replication cycle was well regulated in pathologically low-grade bladder cancer, which did not have chromosomal instability. In contrast, we found marked variability of centrosomes in pathologically high-grade bladder cancer, which had chromosomal instability. CH and CIN were both detected in pathologically high-grade tumors. The grade of CH was directly proportional to the CIN grade (p=0.0079, chi(2) test).The results of the present study suggest that CH may be involved in CIN in bladder cancer." @default.
• W2056475263 created "2016-06-24" @default.
• W2056475263 creator A5005976170 @default.
• W2056475263 creator A5011431391 @default.
• W2056475263 creator A5015435573 @default.
• W2056475263 creator A5025991728 @default.
• W2056475263 creator A5027398117 @default.
• W2056475263 creator A5035143437 @default.
• W2056475263 creator A5049270911 @default.
• W2056475263 creator A5067521653 @default.
• W2056475263 creator A5072873063 @default.
• W2056475263 date "2003-05-01" @default.
• W2056475263 modified "2023-09-26" @default.
• W2056475263 title "Centrosome Hyperamplification and Chromosomal Instability in Bladder Cancer" @default.
• W2056475263 cites W1533958636 @default.
• W2056475263 cites W1588073494 @default.
• W2056475263 cites W1596182601 @default.
• W2056475263 cites W1967149801 @default.
• W2056475263 cites W1991033145 @default.
• W2056475263 cites W1991748238 @default.
• W2056475263 cites W2009017737 @default.
• W2056475263 cites W2018067226 @default.
• W2056475263 cites W2023918529 @default.
• W2056475263 cites W2034498837 @default.
• W2056475263 cites W2040154374 @default.
• W2056475263 cites W2058930011 @default.
• W2056475263 cites W2060963285 @default.
• W2056475263 cites W2061805562 @default.
• W2056475263 cites W2080308138 @default.
• W2056475263 cites W2088179903 @default.
• W2056475263 cites W2178522090 @default.
• W2056475263 cites W2321611063 @default.
• W2056475263 cites W2322441397 @default.
• W2056475263 cites W2331626130 @default.
• W2056475263 cites W2341209396 @default.
• W2056475263 cites W3159164887 @default.
• W2056475263 cites W4297575310 @default.
• W2056475263 cites W4300409071 @default.
• W2056475263 doi "https://doi.org/10.1016/s0302-2838(03)00056-3" @default.
• W2056475263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12705995" @default.
• W2056475263 hasPublicationYear "2003" @default.
• W2056475263 type Work @default.
• W2056475263 sameAs 2056475263 @default.
• W2056475263 citedByCount "30" @default.
• W2056475263 countsByYear W20564752632012 @default.
• W2056475263 countsByYear W20564752632013 @default.
• W2056475263 countsByYear W20564752632019 @default.
• W2056475263 countsByYear W20564752632020 @default.
• W2056475263 countsByYear W20564752632021 @default.
• W2056475263 countsByYear W20564752632023 @default.
• W2056475263 crossrefType "journal-article" @default.
• W2056475263 hasAuthorship W2056475263A5005976170 @default.
• W2056475263 hasAuthorship W2056475263A5011431391 @default.
• W2056475263 hasAuthorship W2056475263A5015435573 @default.
• W2056475263 hasAuthorship W2056475263A5025991728 @default.
• W2056475263 hasAuthorship W2056475263A5027398117 @default.
• W2056475263 hasAuthorship W2056475263A5035143437 @default.
• W2056475263 hasAuthorship W2056475263A5049270911 @default.
• W2056475263 hasAuthorship W2056475263A5067521653 @default.
• W2056475263 hasAuthorship W2056475263A5072873063 @default.
• W2056475263 hasConcept C104317684 @default.
• W2056475263 hasConcept C10447061 @default.
• W2056475263 hasConcept C121608353 @default.
• W2056475263 hasConcept C126322002 @default.
• W2056475263 hasConcept C140752955 @default.
• W2056475263 hasConcept C142724271 @default.
• W2056475263 hasConcept C150194340 @default.
• W2056475263 hasConcept C204232928 @default.
• W2056475263 hasConcept C2777542201 @default.
• W2056475263 hasConcept C2779672484 @default.
• W2056475263 hasConcept C2780352672 @default.
• W2056475263 hasConcept C29537977 @default.
• W2056475263 hasConcept C30481170 @default.
• W2056475263 hasConcept C54355233 @default.
• W2056475263 hasConcept C71924100 @default.
• W2056475263 hasConcept C81439078 @default.
• W2056475263 hasConcept C86803240 @default.
• W2056475263 hasConceptScore W2056475263C104317684 @default.
• W2056475263 hasConceptScore W2056475263C10447061 @default.
• W2056475263 hasConceptScore W2056475263C121608353 @default.
• W2056475263 hasConceptScore W2056475263C126322002 @default.
• W2056475263 hasConceptScore W2056475263C140752955 @default.
• W2056475263 hasConceptScore W2056475263C142724271 @default.
• W2056475263 hasConceptScore W2056475263C150194340 @default.
• W2056475263 hasConceptScore W2056475263C204232928 @default.
• W2056475263 hasConceptScore W2056475263C2777542201 @default.
• W2056475263 hasConceptScore W2056475263C2779672484 @default.
• W2056475263 hasConceptScore W2056475263C2780352672 @default.
• W2056475263 hasConceptScore W2056475263C29537977 @default.
• W2056475263 hasConceptScore W2056475263C30481170 @default.
• W2056475263 hasConceptScore W2056475263C54355233 @default.
• W2056475263 hasConceptScore W2056475263C71924100 @default.
• W2056475263 hasConceptScore W2056475263C81439078 @default.
• W2056475263 hasConceptScore W2056475263C86803240 @default.
• W2056475263 hasIssue "5" @default.
• W2056475263 hasLocation W20564752631 @default.
• W2056475263 hasLocation W20564752632 @default.
• W2056475263 hasOpenAccess W2056475263 @default.

• next