FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056476752> ?p ?o ?g. }

• W2056476752 endingPage "96" @default.
• W2056476752 startingPage "86" @default.
• W2056476752 abstract "Mechanical stretch regulates alpha-smooth muscle actin (SMA) expression in myofibroblasts but limited replication and cellular heterogeneity have hampered definitive studies in vitro. We examined the role of applied force in regulating SMA expression in conditionally immortalized cardiac fibroblast lines derived from H-2Kb-tsA58 transgenic mice. When plated in differentiating conditions (37 degrees C without interferon-gamma), transgenic myofibroblasts exhibited vimentin staining, no desmin staining and abundant SMA in well-developed stress fibers that were indistinguishable from controls. Magnetically-generated tensile forces (approximately 500 pN/cell) applied through collagen-coated magnetite beads selectively reduced SMA but not beta-actin mRNA and protein content in both cell types. The early loss of SMA was due in part to selective leakage into the cell culture medium. Depolymerization of actin filaments with cytochalasin D blocked the force-induced reduction of SMA. Cardiac fibroblast lines established from H-2Kb-tsA58 transgenic mice provide a phenotypically stable source of cells for studying the role of physical forces in regulating SMA." @default.
• W2056476752 created "2016-06-24" @default.
• W2056476752 creator A5014354512 @default.
• W2056476752 creator A5022308392 @default.
• W2056476752 creator A5051002562 @default.
• W2056476752 creator A5051516988 @default.
• W2056476752 date "2001-02-01" @default.
• W2056476752 modified "2023-09-27" @default.
• W2056476752 title "Use of conditionally immortalized mouse cardiac fibroblasts to examine the effect of mechanical stretch on α-smooth muscle actin" @default.
• W2056476752 cites W1523840697 @default.
• W2056476752 cites W1750844586 @default.
• W2056476752 cites W1977815598 @default.
• W2056476752 cites W1984120909 @default.
• W2056476752 cites W2018865025 @default.
• W2056476752 cites W2071864824 @default.
• W2056476752 cites W2082076151 @default.
• W2056476752 cites W2089697406 @default.
• W2056476752 cites W2104628127 @default.
• W2056476752 cites W2106105420 @default.
• W2056476752 cites W2109971798 @default.
• W2056476752 cites W2111528966 @default.
• W2056476752 cites W2161861717 @default.
• W2056476752 cites W2164313332 @default.
• W2056476752 cites W2178451514 @default.
• W2056476752 cites W4254154420 @default.
• W2056476752 doi "https://doi.org/10.1054/tice.2000.0160" @default.
• W2056476752 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11292176" @default.
• W2056476752 hasPublicationYear "2001" @default.
• W2056476752 type Work @default.
• W2056476752 sameAs 2056476752 @default.
• W2056476752 citedByCount "16" @default.
• W2056476752 countsByYear W20564767522013 @default.
• W2056476752 countsByYear W20564767522014 @default.
• W2056476752 countsByYear W20564767522019 @default.
• W2056476752 crossrefType "journal-article" @default.
• W2056476752 hasAuthorship W2056476752A5014354512 @default.
• W2056476752 hasAuthorship W2056476752A5022308392 @default.
• W2056476752 hasAuthorship W2056476752A5051002562 @default.
• W2056476752 hasAuthorship W2056476752A5051516988 @default.
• W2056476752 hasConcept C114614502 @default.
• W2056476752 hasConcept C125705527 @default.
• W2056476752 hasConcept C142669718 @default.
• W2056476752 hasConcept C142724271 @default.
• W2056476752 hasConcept C147447768 @default.
• W2056476752 hasConcept C1491633281 @default.
• W2056476752 hasConcept C153911025 @default.
• W2056476752 hasConcept C161921814 @default.
• W2056476752 hasConcept C203014093 @default.
• W2056476752 hasConcept C204232928 @default.
• W2056476752 hasConcept C207865475 @default.
• W2056476752 hasConcept C2776041460 @default.
• W2056476752 hasConcept C2779072444 @default.
• W2056476752 hasConcept C2780381497 @default.
• W2056476752 hasConcept C2780559512 @default.
• W2056476752 hasConcept C33923547 @default.
• W2056476752 hasConcept C54355233 @default.
• W2056476752 hasConcept C55493867 @default.
• W2056476752 hasConcept C6045943 @default.
• W2056476752 hasConcept C71924100 @default.
• W2056476752 hasConcept C78383274 @default.
• W2056476752 hasConcept C81885089 @default.
• W2056476752 hasConcept C86803240 @default.
• W2056476752 hasConcept C95444343 @default.
• W2056476752 hasConceptScore W2056476752C114614502 @default.
• W2056476752 hasConceptScore W2056476752C125705527 @default.
• W2056476752 hasConceptScore W2056476752C142669718 @default.
• W2056476752 hasConceptScore W2056476752C142724271 @default.
• W2056476752 hasConceptScore W2056476752C147447768 @default.
• W2056476752 hasConceptScore W2056476752C1491633281 @default.
• W2056476752 hasConceptScore W2056476752C153911025 @default.
• W2056476752 hasConceptScore W2056476752C161921814 @default.
• W2056476752 hasConceptScore W2056476752C203014093 @default.
• W2056476752 hasConceptScore W2056476752C204232928 @default.
• W2056476752 hasConceptScore W2056476752C207865475 @default.
• W2056476752 hasConceptScore W2056476752C2776041460 @default.
• W2056476752 hasConceptScore W2056476752C2779072444 @default.
• W2056476752 hasConceptScore W2056476752C2780381497 @default.
• W2056476752 hasConceptScore W2056476752C2780559512 @default.
• W2056476752 hasConceptScore W2056476752C33923547 @default.
• W2056476752 hasConceptScore W2056476752C54355233 @default.
• W2056476752 hasConceptScore W2056476752C55493867 @default.
• W2056476752 hasConceptScore W2056476752C6045943 @default.
• W2056476752 hasConceptScore W2056476752C71924100 @default.
• W2056476752 hasConceptScore W2056476752C78383274 @default.
• W2056476752 hasConceptScore W2056476752C81885089 @default.
• W2056476752 hasConceptScore W2056476752C86803240 @default.
• W2056476752 hasConceptScore W2056476752C95444343 @default.
• W2056476752 hasIssue "1" @default.
• W2056476752 hasLocation W20564767521 @default.
• W2056476752 hasLocation W20564767522 @default.
• W2056476752 hasOpenAccess W2056476752 @default.
• W2056476752 hasPrimaryLocation W20564767521 @default.
• W2056476752 hasRelatedWork W1218841746 @default.
• W2056476752 hasRelatedWork W2040135427 @default.
• W2056476752 hasRelatedWork W2056476752 @default.
• W2056476752 hasRelatedWork W2062332518 @default.
• W2056476752 hasRelatedWork W2078063949 @default.
• W2056476752 hasRelatedWork W2113834476 @default.

• next