FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056479947> ?p ?o ?g. }

• W2056479947 endingPage "e1003397" @default.
• W2056479947 startingPage "e1003397" @default.
• W2056479947 abstract "Acute resistance to low dose M. tuberculosis (Mtb) infection is not dependent on Toll-like receptor (TLR) 2. However, whether TLR2 contributes to resistance in chronic Mtb infection has remained uncertain. Here we report that, following low dose aerosol infection with Mtb, mice lacking TLR2 (TLR2KO), in comparison with wild type (WT) mice, exhibit enhanced cellular infiltration and inflammation in the lungs, and fail to stably control bacterial burden during chronic infection. IFNγ and IL-17 was expressed at equivalent levels in the two groups; however, the characteristic accumulation of Foxp3+ T regulatory cells (Tregs) in pulmonary granulomas was significantly reduced in TLR2KO mice. Nonetheless, this reduction in Tregs was independent of whether Tregs expressed TLR2 or not. To directly link the reduced number of Tregs to the increased inflammation present in the TLR2KO mice, we used a macrophage adoptive transfer model. At seven weeks post-Mtb infection, TLR2KO mice, which were adoptively transferred with WT macrophages, displayed enhanced accumulation of Tregs in the lungs and a concomitant reduction in inflammation in contrast with control mice that received TLR2KO macrophages. However, the pulmonary bacterial burden between the two groups remained similar indicating that TLR2's role in modulating immunopathology is functionally distinct from its role in restricting Mtb growth in chronic infection. Together, these findings unequivocally demonstrate that TLR2 contributes to host resistance against chronic Mtb infection and reveal a novel role for TLR2 in mediating the recruitment of Foxp3+ Tregs to the lungs to control inflammation." @default.
• W2056479947 created "2016-06-24" @default.
• W2056479947 creator A5003448964 @default.
• W2056479947 creator A5004339100 @default.
• W2056479947 creator A5028310069 @default.
• W2056479947 date "2013-06-13" @default.
• W2056479947 modified "2023-09-24" @default.
• W2056479947 title "Host Defense and Recruitment of Foxp3+ T Regulatory Cells to the Lungs in Chronic Mycobacterium tuberculosis Infection Requires Toll-like Receptor 2" @default.
• W2056479947 cites W1489330398 @default.
• W2056479947 cites W1554415411 @default.
• W2056479947 cites W1572384585 @default.
• W2056479947 cites W1588790881 @default.
• W2056479947 cites W1627009127 @default.
• W2056479947 cites W1683960100 @default.
• W2056479947 cites W1744462629 @default.
• W2056479947 cites W1852410481 @default.
• W2056479947 cites W1919349212 @default.
• W2056479947 cites W1960939533 @default.
• W2056479947 cites W1965390251 @default.
• W2056479947 cites W1967305091 @default.
• W2056479947 cites W1980416201 @default.
• W2056479947 cites W1984543828 @default.
• W2056479947 cites W1987735044 @default.
• W2056479947 cites W1988681127 @default.
• W2056479947 cites W1998872820 @default.
• W2056479947 cites W2000899720 @default.
• W2056479947 cites W2014679097 @default.
• W2056479947 cites W2019169633 @default.
• W2056479947 cites W2023478821 @default.
• W2056479947 cites W2026190085 @default.
• W2056479947 cites W2035163170 @default.
• W2056479947 cites W2040544951 @default.
• W2056479947 cites W2040549498 @default.
• W2056479947 cites W2048884877 @default.
• W2056479947 cites W2049449911 @default.
• W2056479947 cites W2052283409 @default.
• W2056479947 cites W2054974176 @default.
• W2056479947 cites W2057809738 @default.
• W2056479947 cites W2059678333 @default.
• W2056479947 cites W2060493356 @default.
• W2056479947 cites W2064964564 @default.
• W2056479947 cites W2071723955 @default.
• W2056479947 cites W2085257327 @default.
• W2056479947 cites W2087724831 @default.
• W2056479947 cites W2090697934 @default.
• W2056479947 cites W2091229884 @default.
• W2056479947 cites W2091835252 @default.
• W2056479947 cites W2097509788 @default.
• W2056479947 cites W2100235293 @default.
• W2056479947 cites W2101318521 @default.
• W2056479947 cites W2102467166 @default.
• W2056479947 cites W2102738624 @default.
• W2056479947 cites W2109152623 @default.
• W2056479947 cites W2110714188 @default.
• W2056479947 cites W2120459807 @default.
• W2056479947 cites W2124580054 @default.
• W2056479947 cites W2126245681 @default.
• W2056479947 cites W2129786694 @default.
• W2056479947 cites W2129869755 @default.
• W2056479947 cites W2137668986 @default.
• W2056479947 cites W2138582125 @default.
• W2056479947 cites W2139593091 @default.
• W2056479947 cites W2144675149 @default.
• W2056479947 cites W2145457161 @default.
• W2056479947 cites W2146396140 @default.
• W2056479947 cites W2146839864 @default.
• W2056479947 cites W2148637160 @default.
• W2056479947 cites W2150059429 @default.
• W2056479947 cites W2150678612 @default.
• W2056479947 cites W2153234950 @default.
• W2056479947 cites W2160670021 @default.
• W2056479947 cites W2161273761 @default.
• W2056479947 cites W2161784221 @default.
• W2056479947 cites W2161868263 @default.
• W2056479947 cites W2162012576 @default.
• W2056479947 cites W2163437751 @default.
• W2056479947 doi "https://doi.org/10.1371/journal.ppat.1003397" @default.
• W2056479947 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3681744" @default.
• W2056479947 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23785280" @default.
• W2056479947 hasPublicationYear "2013" @default.
• W2056479947 type Work @default.
• W2056479947 sameAs 2056479947 @default.
• W2056479947 citedByCount "46" @default.
• W2056479947 countsByYear W20564799472013 @default.
• W2056479947 countsByYear W20564799472014 @default.
• W2056479947 countsByYear W20564799472015 @default.
• W2056479947 countsByYear W20564799472016 @default.
• W2056479947 countsByYear W20564799472017 @default.
• W2056479947 countsByYear W20564799472018 @default.
• W2056479947 countsByYear W20564799472019 @default.
• W2056479947 countsByYear W20564799472020 @default.
• W2056479947 countsByYear W20564799472021 @default.
• W2056479947 countsByYear W20564799472022 @default.
• W2056479947 countsByYear W20564799472023 @default.
• W2056479947 crossrefType "journal-article" @default.
• W2056479947 hasAuthorship W2056479947A5003448964 @default.
• W2056479947 hasAuthorship W2056479947A5004339100 @default.
• W2056479947 hasAuthorship W2056479947A5028310069 @default.

• next