FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056482685> ?p ?o ?g. }

• W2056482685 endingPage "55" @default.
• W2056482685 startingPage "49" @default.
• W2056482685 abstract "Tranilast (TL) composite particles with α-glucosyl rutin (Rutin-G) were developed to improve the solubility and oral bioavailability of TL. Composite formulation of TL/Rutin-G was prepared using the spray-drying method, and their physicochemical properties were evaluated with respect to the morphology, particle size distribution, solubility and crystallinity. The nanostructure formation of Rutin-G was characterized by dynamic light scattering and transmission electron microscopy when Rutin-G or TL/Rutin-G spray-dried particles (SDPs) were introduced into water. A pharmacokinetic study was also performed to assess the improvement of oral absorption in rats. TL/Rutin-G SDPs were spherical particles with a diameter of 5.5 μm. Even in the acidic condition, the remarkable improvement in solubility of TL was achieved, as evidenced by a 32.2-fold increase in solubility compared with untreated TL. The median size of Rutin-G nanostructures in water was 2 nm. The formation of Rutin-G nanostructures and their drug inclusion properties may enhance the solubility and dissolution behavior of TL. A drastic increase was found in the exposure of TL in rats, with an increase in Cmax and AUC values of 114- and 36.4-fold, respectively, compared with those of untreated TL. These findings indicated that a TL formulation spray-dried with Rutin-G could enhance its solubility and absorption and thus its therapeutic properties." @default.
• W2056482685 created "2016-06-24" @default.
• W2056482685 creator A5029273496 @default.
• W2056482685 creator A5038640614 @default.
• W2056482685 creator A5041195742 @default.
• W2056482685 creator A5052577338 @default.
• W2056482685 creator A5058359940 @default.
• W2056482685 creator A5080893014 @default.
• W2056482685 creator A5088074277 @default.
• W2056482685 date "2015-05-01" @default.
• W2056482685 modified "2023-09-26" @default.
• W2056482685 title "Absorption improvement of tranilast by forming highly soluble nano-size composite structures associated with α-glucosyl rutin via spray drying" @default.
• W2056482685 cites W1498305210 @default.
• W2056482685 cites W1970991512 @default.
• W2056482685 cites W1972125312 @default.
• W2056482685 cites W1977446006 @default.
• W2056482685 cites W1987820544 @default.
• W2056482685 cites W1994718982 @default.
• W2056482685 cites W1999800584 @default.
• W2056482685 cites W2003566226 @default.
• W2056482685 cites W2003583241 @default.
• W2056482685 cites W2005479419 @default.
• W2056482685 cites W2010980902 @default.
• W2056482685 cites W2014879978 @default.
• W2056482685 cites W2025331820 @default.
• W2056482685 cites W2030883001 @default.
• W2056482685 cites W2030951340 @default.
• W2056482685 cites W2036327919 @default.
• W2056482685 cites W2044388178 @default.
• W2056482685 cites W2056853058 @default.
• W2056482685 cites W2058107505 @default.
• W2056482685 cites W2059702989 @default.
• W2056482685 cites W2062066769 @default.
• W2056482685 cites W2083353542 @default.
• W2056482685 cites W2088088475 @default.
• W2056482685 cites W2088465869 @default.
• W2056482685 cites W2095681856 @default.
• W2056482685 cites W2101171473 @default.
• W2056482685 cites W2107559581 @default.
• W2056482685 cites W2129730934 @default.
• W2056482685 cites W2154666367 @default.
• W2056482685 cites W2171824424 @default.
• W2056482685 cites W2952528349 @default.
• W2056482685 cites W4252055886 @default.
• W2056482685 doi "https://doi.org/10.1016/j.ejpb.2015.02.021" @default.
• W2056482685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25725261" @default.
• W2056482685 hasPublicationYear "2015" @default.
• W2056482685 type Work @default.
• W2056482685 sameAs 2056482685 @default.
• W2056482685 citedByCount "27" @default.
• W2056482685 countsByYear W20564826852015 @default.
• W2056482685 countsByYear W20564826852016 @default.
• W2056482685 countsByYear W20564826852017 @default.
• W2056482685 countsByYear W20564826852018 @default.
• W2056482685 countsByYear W20564826852019 @default.
• W2056482685 countsByYear W20564826852021 @default.
• W2056482685 countsByYear W20564826852022 @default.
• W2056482685 countsByYear W20564826852023 @default.
• W2056482685 crossrefType "journal-article" @default.
• W2056482685 hasAuthorship W2056482685A5029273496 @default.
• W2056482685 hasAuthorship W2056482685A5038640614 @default.
• W2056482685 hasAuthorship W2056482685A5041195742 @default.
• W2056482685 hasAuthorship W2056482685A5052577338 @default.
• W2056482685 hasAuthorship W2056482685A5058359940 @default.
• W2056482685 hasAuthorship W2056482685A5080893014 @default.
• W2056482685 hasAuthorship W2056482685A5088074277 @default.
• W2056482685 hasConcept C125287762 @default.
• W2056482685 hasConcept C127413603 @default.
• W2056482685 hasConcept C13965031 @default.
• W2056482685 hasConcept C147789679 @default.
• W2056482685 hasConcept C155574463 @default.
• W2056482685 hasConcept C159985019 @default.
• W2056482685 hasConcept C178790620 @default.
• W2056482685 hasConcept C181389837 @default.
• W2056482685 hasConcept C185592680 @default.
• W2056482685 hasConcept C187530423 @default.
• W2056482685 hasConcept C192562407 @default.
• W2056482685 hasConcept C2775963812 @default.
• W2056482685 hasConcept C2778004101 @default.
• W2056482685 hasConcept C2779587474 @default.
• W2056482685 hasConcept C2780269026 @default.
• W2056482685 hasConcept C42360764 @default.
• W2056482685 hasConcept C43617362 @default.
• W2056482685 hasConcept C46275449 @default.
• W2056482685 hasConcept C71924100 @default.
• W2056482685 hasConcept C8010536 @default.
• W2056482685 hasConcept C88380143 @default.
• W2056482685 hasConcept C98274493 @default.
• W2056482685 hasConceptScore W2056482685C125287762 @default.
• W2056482685 hasConceptScore W2056482685C127413603 @default.
• W2056482685 hasConceptScore W2056482685C13965031 @default.
• W2056482685 hasConceptScore W2056482685C147789679 @default.
• W2056482685 hasConceptScore W2056482685C155574463 @default.
• W2056482685 hasConceptScore W2056482685C159985019 @default.
• W2056482685 hasConceptScore W2056482685C178790620 @default.
• W2056482685 hasConceptScore W2056482685C181389837 @default.
• W2056482685 hasConceptScore W2056482685C185592680 @default.
• W2056482685 hasConceptScore W2056482685C187530423 @default.

• next