FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056490516> ?p ?o ?g. }

• W2056490516 endingPage "139" @default.
• W2056490516 startingPage "133" @default.
• W2056490516 abstract "Heat shock proteins (HSPs) are intracellular proteins which function as molecular chaperones. At the same time, translocation of HSPs to the cell surface has been observed in stressed, infected and transformed cells. It seems plausible that surface HSPs may represent molecular targets for recognition and elimination of 'altered' cells by cytotoxic lymphocytes. Previously we demonstrated that EL-4 mouse lymphoma cells growing in vitro express HSPs on their plasma membrane. In this study, we tested the hypothesis that surface HSPs present on EL-4 cells may mediate their recognition and killing by cytotoxic lymphocytes. We have found that susceptibility of culture-adapted EL-4 cells to in vitro lysis by syngeneic and allogeneic splenocytes correlated with the expression of HSP70 on EL-4 cells. Moreover, cytotoxicity was blocked by pretreatment of EL-4 target cells with anti-HSP70 antibody, whereas antibodies to MHC class I molecules and Thy1 did not have such effect. Cytotoxicity against EL-4 lymphoma was not MHC class I-restricted, and was not decreased after depletion of CD8(+) cells from the effector cell population. We conclude that in vitro killing of EL-4 cells is mediated, at least in part, by NK cells via recognition of HSPs present on the surface of tumor cells. Thus, cytotoxic response against EL-4 lymphoma should serve as a good model to study the role of HSPs in anti-tumor immunity." @default.
• W2056490516 created "2016-06-24" @default.
• W2056490516 creator A5018460910 @default.
• W2056490516 creator A5083908352 @default.
• W2056490516 creator A5089745661 @default.
• W2056490516 date "2000-10-01" @default.
• W2056490516 modified "2023-09-24" @default.
• W2056490516 title "Splenic cytotoxic cells recognize surface HSP70 on culture-adapted EL-4 mouse lymphoma cells" @default.
• W2056490516 cites W1483170373 @default.
• W2056490516 cites W1723790989 @default.
• W2056490516 cites W1850381170 @default.
• W2056490516 cites W1891674078 @default.
• W2056490516 cites W1967939624 @default.
• W2056490516 cites W1974412246 @default.
• W2056490516 cites W1976161875 @default.
• W2056490516 cites W1989709588 @default.
• W2056490516 cites W1989770318 @default.
• W2056490516 cites W2001851977 @default.
• W2056490516 cites W2008809605 @default.
• W2056490516 cites W2009332729 @default.
• W2056490516 cites W2015763364 @default.
• W2056490516 cites W2019499844 @default.
• W2056490516 cites W2020622526 @default.
• W2056490516 cites W2022804455 @default.
• W2056490516 cites W2040120059 @default.
• W2056490516 cites W2048836045 @default.
• W2056490516 cites W2050889159 @default.
• W2056490516 cites W2060944813 @default.
• W2056490516 cites W2085640213 @default.
• W2056490516 cites W2085694842 @default.
• W2056490516 cites W2087741730 @default.
• W2056490516 cites W2104971075 @default.
• W2056490516 cites W2122702136 @default.
• W2056490516 cites W2154892697 @default.
• W2056490516 cites W2403197275 @default.
• W2056490516 cites W2435501756 @default.
• W2056490516 doi "https://doi.org/10.1016/s0165-2478(00)00256-x" @default.
• W2056490516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10996389" @default.
• W2056490516 hasPublicationYear "2000" @default.
• W2056490516 type Work @default.
• W2056490516 sameAs 2056490516 @default.
• W2056490516 citedByCount "17" @default.
• W2056490516 countsByYear W20564905162014 @default.
• W2056490516 countsByYear W20564905162015 @default.
• W2056490516 countsByYear W20564905162018 @default.
• W2056490516 countsByYear W20564905162019 @default.
• W2056490516 crossrefType "journal-article" @default.
• W2056490516 hasAuthorship W2056490516A5018460910 @default.
• W2056490516 hasAuthorship W2056490516A5083908352 @default.
• W2056490516 hasAuthorship W2056490516A5089745661 @default.
• W2056490516 hasConcept C104317684 @default.
• W2056490516 hasConcept C147483822 @default.
• W2056490516 hasConcept C153911025 @default.
• W2056490516 hasConcept C154317977 @default.
• W2056490516 hasConcept C167672396 @default.
• W2056490516 hasConcept C170627219 @default.
• W2056490516 hasConcept C202751555 @default.
• W2056490516 hasConcept C203014093 @default.
• W2056490516 hasConcept C205260736 @default.
• W2056490516 hasConcept C207936829 @default.
• W2056490516 hasConcept C2908647359 @default.
• W2056490516 hasConcept C55493867 @default.
• W2056490516 hasConcept C71924100 @default.
• W2056490516 hasConcept C86803240 @default.
• W2056490516 hasConcept C95444343 @default.
• W2056490516 hasConcept C99454951 @default.
• W2056490516 hasConceptScore W2056490516C104317684 @default.
• W2056490516 hasConceptScore W2056490516C147483822 @default.
• W2056490516 hasConceptScore W2056490516C153911025 @default.
• W2056490516 hasConceptScore W2056490516C154317977 @default.
• W2056490516 hasConceptScore W2056490516C167672396 @default.
• W2056490516 hasConceptScore W2056490516C170627219 @default.
• W2056490516 hasConceptScore W2056490516C202751555 @default.
• W2056490516 hasConceptScore W2056490516C203014093 @default.
• W2056490516 hasConceptScore W2056490516C205260736 @default.
• W2056490516 hasConceptScore W2056490516C207936829 @default.
• W2056490516 hasConceptScore W2056490516C2908647359 @default.
• W2056490516 hasConceptScore W2056490516C55493867 @default.
• W2056490516 hasConceptScore W2056490516C71924100 @default.
• W2056490516 hasConceptScore W2056490516C86803240 @default.
• W2056490516 hasConceptScore W2056490516C95444343 @default.
• W2056490516 hasConceptScore W2056490516C99454951 @default.
• W2056490516 hasIssue "2" @default.
• W2056490516 hasLocation W20564905161 @default.
• W2056490516 hasLocation W20564905162 @default.
• W2056490516 hasOpenAccess W2056490516 @default.
• W2056490516 hasPrimaryLocation W20564905161 @default.
• W2056490516 hasRelatedWork W1526433952 @default.
• W2056490516 hasRelatedWork W1589818703 @default.
• W2056490516 hasRelatedWork W1982121321 @default.
• W2056490516 hasRelatedWork W2032441316 @default.
• W2056490516 hasRelatedWork W2046341790 @default.
• W2056490516 hasRelatedWork W2055271950 @default.
• W2056490516 hasRelatedWork W2056004315 @default.
• W2056490516 hasRelatedWork W2413098560 @default.
• W2056490516 hasRelatedWork W247953896 @default.
• W2056490516 hasRelatedWork W4282919193 @default.
• W2056490516 hasVolume "74" @default.

• next