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• W2056500071 abstract "Denys–Drash syndrome (DDS) is characterized by progressive glomerulopathy caused by diffuse mesangial sclerosis (DMS), genitourinary defects, and a higher risk of developing Wilms’ tumor. It is commonly assumed that the DMS is unresponsive to any medications. In this report, we present a patient with Denys–Drash syndrome, in whom the cyclosporine A (CsA) was found to induce total remission. This observation and observations of other authors confirm that in genetic forms of nephrotic syndrome, the proteinuric effect of CsA may be due to a non-immunologic mechanism. We confirm the beneficial effect of CsA treatment in DDS; however, the potential nephrotoxicity of this drug will probably not allow long-term use." @default.
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• W2056500071 date "2010-09-17" @default.
• W2056500071 modified "2023-10-14" @default.
• W2056500071 title "Effect of cyclosporin A on proteinuria in the course of glomerulopathy associated with WT1 mutations" @default.
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• W2056500071 doi "https://doi.org/10.1007/s00431-010-1278-4" @default.
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