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- W2056500194 abstract "To test the hypothesis that dexamethasone (Dex) treatment would restore rat hepatic bile acid coenzyme A-amino acid N-acyltransferase (rBAT) expression in septic rats after cecal ligation and puncture by increasing expression of retinoic acid X receptor α (RXRα), we assessed survival rate and bile and bile salt concentration in the Dex-treated septic group and compared these results with those for a nontreated septic group, a Dex-treated nonseptic group, and a sham group. Dexamethasone treatment (0.01 mg/kg) significantly improved the survival rate and increased the bile and bile salt concentration in the bile ducts of septic rats (P = <0.05). In our assessment of bile salt-related genes, during sepsis, there were decreases in protein and mRNA expression of rBAT and cholesterol 7 alpha-hydroxylase (CYP7A1). Treatment with Dex restored expression of rBAT and RXRα but not CYP7A1, bile salt export pump, or multidrug resistance associated protein 2 (MRP2). Na+-taurocholate cotransport protein and organic anion transporting polypeptide 1 were unchanged. In addition, treatment with Dex also restored the DNA-binding activity of RXR/farnesoid-X receptor to rBAT promoter containing inverted repeat 1 sequence. In an experiment to confirm our findings, RXRα siRNA was found to significantly block Dex-induced increases in expression of rBAT in hepatocytes taken from septic rats (P < 0.01). Conclusion-Dex restored the expression of rBAT in septic rats by enhancing RXRα, a process that might explain the mechanism underlying Dex's anticholestatic effect." @default.
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- W2056500194 date "2009-08-01" @default.
- W2056500194 modified "2023-09-28" @default.
- W2056500194 title "RETINOID X RECEPTOR α PARTICIPATION IN DEXAMETHASONE-INDUCED RAT BILE ACID COENZYME A-AMINO ACID N-ACYLTRANSFERASE EXPRESSION IN SEPTIC LIVER" @default.
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- W2056500194 doi "https://doi.org/10.1097/shk.0b013e318193e063" @default.
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