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- W2056500208 abstract "Human N-myristoyltransferase 1 (hNMT-1) catalyzes the covalent attachment of myristic acid to N-terminal glycine residues (myristoylation) of numerous protein substrates. Overexpression of hNMT-1 in colorectal and gallbladder cancers makes it a potential biomarker and drug design target for such cancers. In this study, we investigated hNMT-1 expression during the progression of eight different human cancers using quantitative RT-PCR. The study results showed that hNMT-1 was up-regulated in breast, colon, lung and ovarian cancers but not kidney, liver, prostate and thyroid cancers. This suggests a role for hNMT-1 as a biomarker for detection of breast, colon, lung and ovarian cancers. This study also suggests the available hNMT-1 inhibitors may be potential therapeutic agents against breast and lung cancers through all disease stages, although their use would likely be limited to early stage colon and ovarian cancers." @default.
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- W2056500208 date "2009-03-13" @default.
- W2056500208 modified "2023-10-12" @default.
- W2056500208 title "Quantitative Analysis of the Expression of Human N-myristoyltransferase 1 (hNMT-1) in Cancers" @default.
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- W2056500208 doi "https://doi.org/10.2174/1875318300902010006" @default.
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